PENGARUH PEMBERIAN EKSTRAK DAUN TEH HIJAU (Camellia sinensis) TERHADAP KADAR SGPT TIKUS PUTIH ( Rattus novergicus ) YANG DIINDUKSI ISONIAZID

HIMAWAN, ROSANDI (2008) PENGARUH PEMBERIAN EKSTRAK DAUN TEH HIJAU (Camellia sinensis) TERHADAP KADAR SGPT TIKUS PUTIH ( Rattus novergicus ) YANG DIINDUKSI ISONIAZID. Other thesis, Universitas Sebelas Maret Surakarta .

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    Abstract

    Green tea (Camellia sinenses) contains polifenol agent which is noticed as catechin, its consist of epicatechin, epicatechin-3-gallate, epigallocatechin, and epigallocathecin-3-gallate. Many studies proved that these agents act as hepatoprotector from reactive oxygen species (ROS) by gluthation-S-transferase (GST) increasing and ROS neutralizing. Isoniazid as a liver damage model was used in these research. This damage could be detect by SGPT level measuring. The purpose of this experiment is to know the effect of given extract green tea at SGPT rate in rat inducted by Isoniazid. This in a pure experimental research with pre and posttest controlled groups design. These research used 30 white rat (Ratus novergicus) of Wistar strain within the age of 3 month and 200 gram of weigh. These rat divided in 5 groups that consist of 6 rats for each. Group I was negative control group that gave pellet ad libitun standard dietary only. Group II was positive control group that gave standard dietary and isoniazid (INH) within 30 mg/200 gram body weight dosage. Group III was group I that acted as positive control group added with 20mg/200gram body weight dosage of green tea extract. Group IV was group II as positive control group added with 40 mg/200 gram body weight dosage of green tea extract. Group V was group III as positive control added with 60 mg/200 gram body weight dosage of green tea extract. This research took 21 day, at fouth day blood was taken from sinus orbitalis, then early SGPT was measured and at he 21th day late SGPT was measured. One way Anova statistical analysis was used to analyze the range of early and late SGPT levels. Furthermore, this analysis was continued with Least Significant Different/Fisher (LSD) methode of Post Hoc Test within α=0.05 used SPSS for Windows Release 15. The result deciphered that average SGPT levels between group K(-) and K(+) was distinguish statistically within p: 0.0000 (p,0.05). There was a differences of average SGPT levels in group k(-) and P1 that statistically proved within p: 0.000 (p<0.05). there was no statistically proved differences of average SGPT levels within p: 0.272 (p<0.05). Beside this, there was a different of average SGPT levels that statistically proved within p: 0.049 (p<0.05). It was concluded that giving green tea extract can act as hepatoprotector for white rat induced by isoniazid. Keywords : Camellia sinensis, Isoniazid, SGPT

    Item Type: Thesis (Other)
    Subjects: R Medicine > R Medicine (General)
    Divisions: Fakultas Kedokteran
    Fakultas Kedokteran > Pendidikan Kedokteran
    Depositing User: Riza Umami Nur K
    Date Deposited: 24 Jul 2013 20:38
    Last Modified: 24 Jul 2013 20:38
    URI: https://eprints.uns.ac.id/id/eprint/8951

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