Uji Antimalaria Ekstrak Buah Morinda citrifolia dan Aktivitas Makrofag pada Mencit (Mus musculus) setelah Diinfeksi Plasmodium berghei

HUTOMO, RAHADI and SUTARNO, and WINARNO, WIEN and KUSMARDI, (2005) Uji Antimalaria Ekstrak Buah Morinda citrifolia dan Aktivitas Makrofag pada Mencit (Mus musculus) setelah Diinfeksi Plasmodium berghei. Biofarmasi, 3 (2). pp. 61-69. ISSN 1693-2242

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    Abstract

    Malaria is a world wide disease. Death resulting from the disease was caused by the parasite’s resistance to the malaria drugs and the problem of immune system. The aims of the research were to know the effect of M. citrifolia fruit extract to Plasmodium berghei on total red blood cells of mice, and to know the effect of the extract on the number of intraperitoneal macrophage phagositosing latex after infected by P. berghei. Three doses of fruit extract, 200, 150, 100 mg/kg BB were used in this study. Fansidar was used as positive control, while destilled water was used as negative control. The result of this research indicated that dose of 200 mg/kg BB could reduce number of parasitemia to 3.576%, dose of 150 mg/kg BB to 4.107%, and dose of 100 mg/kg BB to 13.331% on day 5, and could not reduce any number of parasitemia on the next day. Inhibition by Fansidar reached 0.201%, while distilled water did not show any inhibition activity. Different macrophage activity on phagositosing latex was taken place. The average of macrophage activity on phagositosing latex at dose of 200 mg/kg BB was 3.8x106 cell, at dose of 150 mg/kg BB was 2.53x106 cell/mL, while at dose 100 mg/kg BB was 1.5x106 cell/mL, and 2.43x106 cell/mL for the control. Based on the results of the study, it can be concluded that the reduction of the number of parasitemia taken place at dose 200 and 150 mg/kg BB, although its activity is much lower than malaria drug of Fansidar. Macrophage activities increased at dose of 200 mg/kg BB. Key words: malaria, Morinda citrifolia, parasitemia, Plasmodium berghei, macrophage.

    Item Type: Article
    Subjects: Q Science > Q Science (General)
    Divisions: Fakultas Matematika dan Ilmu Pengetahuan Alam > Biologi
    Depositing User: mr azis r
    Date Deposited: 21 May 2013 19:24
    Last Modified: 21 May 2013 19:24
    URI: https://eprints.uns.ac.id/id/eprint/790

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