PENGARUH BAYAM ANTING (Acalypha indica L.) TERHADAP KADAR KOLESTEROL PADA MENCIT BALB/C PAPARAN STREPTOZOTOCIN

AMPAISA, ANESY PUTRI (2011) PENGARUH BAYAM ANTING (Acalypha indica L.) TERHADAP KADAR KOLESTEROL PADA MENCIT BALB/C PAPARAN STREPTOZOTOCIN. Masters thesis, Universitas Sebelas Maret.

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    Abstract

    ABSTRAK Anesy Putri Ampaisa, G0005035, 2011, Pengaruh Bayam Anting (Acalypha indica L.) terhadap Kadar Kolesterol pada Mencit Balb/C Paparan Streptozotocin, Fakultas Kedokteran, Universitas Sebelas Maret, Surakarta. Tujuan Penelitian : Tujuan penelitian ini adalah untuk mengetahui Pengaruh Bayam Anting (Acalypha indica, L.) terhadap Kadar Kolesterol pada Mencit Balb/C Paparan Streptozotocin. Metode Penelitian : Penelitian ini bersifat eksperimental laboratorik dengan the Post Test Only Control Group Design. Penelitian dilakukan di Laboratorium Histologi Universitas Sebelas Maret, Surakarta. Subjek Penelitian adalah 18 ekor mencit jantan, berumur 4-6 minggu, berat badan 20 - 30 gram di bagi dalam 3 kelompok, masing - masing 6 ekor. K1 kelompok DM. K2 kelompok diberi ekstrak Bayam Anting dosis 1.000 mg/kgBB/hari. K3 kelompok diberi OHO Metformin dosis 1,3 mg/kgBB/hari. Pengukuran kadar kolesterol dilakukan minggu kedua setelah perlakuan. Data yang diperoleh dianalisis dengan uji statistik One-Way Anova dan dilanjutkan dengan LSD Post Hoc Test, menggunakan program SPSS for Windows Release 17. Perbedaan signifikan bila p<0,05. Hasil Penelitian : Penelitian ini menunjukan rerata kadar kolesterol total pada kelompok K1 yaitu (119,17 mg/dl), kelompok K2 yaitu (131,67 mg/dl), dan kelompok K3 yaitu (110,00 mg/dl). Hasil uji One-Way Anova menunjukkan adanya perbedaan pada 3 kelompok penelitian secara bermakana p=0,037 (p0,05). Hasil uji statistik LSD menunjukkan perbedaan yang tidak bermakna antara kelompok K1 dengan K2 (p=0,119), K1 dengan K3 (p=0,244) dan terdapat perbedaan yang bermakna antara kelompok K2 dengan K3 (p=0,012). Simpulan Penelitian : Hasil penelitian menunjukkan bahwa pemberian ekstrak Bayam Anting (Acalypha indica, L.) dosis 1000 mg/kgBB/hari tidak mempunyai efek menurunkan kadar kolesterol mencit Balb/C induksi streptozotocin. Kata kunci : Bayam Anting, Kadar Kolesterol, Streptozotocin, Diabetes Melitus ABSTRACT Anesy Putri Ampaisa, G0005035, 2010. The Effect of Bayam Anting (Acalypha indica, L.) with the Cholesterol Levels of Balb/C Mice Induced Streptozotocin, Faculty of Medicine, Sebelas Maret University, Surakarta. Objective : This research aimed to examine the effect of Bayam Anting (Acalypha indica, L.) with the serum cholesterol of mice Balb/C induced streptozotocin. Methods : This research is laboratoric experimental with the Post Test Only Control Group Design. It was conducted in the histologi Laboratory of Sebelas maret University, Surakarta. The subjects of this research were 18 male mice, aged between four to six weeks and weiged between 20 - 30 grams. They were divided into three groups, each of which consisted of six white rats. K1 was DM group. K2 was given Acalypha indica L. with the dosage of 1000 mg/kgBB. K3 was given OHO metformin with the dosage of 1,3 mg/kgBB. The cholesterol levels was measured after two weeks of the treatment. The data was analysed with One-Way Anova test and was continued with LSD Post Hoc Test, using SPSS for Window Release 17 program. The difference were stated significant if the p<0,05. Results : This research showed the mean of total cholesterol of the first group (K1) is (119,17 mg/dl), the second group (K2) is (131,67 mg/dl), and the third group (K3) is (110,00 mg/dl). The result of One-Way Anova test show that is significant difference between three group p=0,037 (p0,05). The result of LSD statistic test shows that there did not significant difference between K1 group and K2 (p=0,119), K1 group and K3 (p=0,244), and there were significant difference between K2 group and K3 (p=0,012) Conclussion : The experiment result showed that Bayam Anting (Acalypha indica, L.) extract doses 1000 mg/kg body weight/day did not have any effect in lowering total cholesterol in Balb/C mice induced streptozotocin. Keyword : Acalypha indica L, cholesterol levels, Streptozotocin, Diabetes Mellitus

    Item Type: Thesis (Masters)
    Uncontrolled Keywords: Bayam Anting, Kadar Kolesterol, Streptozotocin, Diabetes Melitus
    Subjects: R Medicine > R Medicine (General)
    Divisions: Fakultas Kedokteran > Pendidikan Kedokteran
    Depositing User: Fairly Okta'mal
    Date Deposited: 20 Jul 2013 05:32
    Last Modified: 20 Jul 2013 05:32
    URI: https://eprints.uns.ac.id/id/eprint/7136

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