EFEK HEPATOPROTEKTOR JUS SEMANGKA MERAH (Citrulus vulgaris) TERHADAPKERUSAKAN SEL HEPAR TIKUS PUTIH (Rattus norvegicus) AKIBAT PAPARAN PARASETAMOL

YUGO, HARDITO PUSPO (2011) EFEK HEPATOPROTEKTOR JUS SEMANGKA MERAH (Citrulus vulgaris) TERHADAPKERUSAKAN SEL HEPAR TIKUS PUTIH (Rattus norvegicus) AKIBAT PAPARAN PARASETAMOL. Other thesis, Universitas Sebelas Maret.

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    Abstract

    Objective: The objectives of this research are to know the influence of watermelon juice to liver histological damage of rats which is induced by paracetamol and whether the increase of watermelon juice dose can also increase protection effect to the liver histological damage of rats which is induced by paracetamol.. Methods: This was laboratory experimental research with the post test only controlled group design. Samples were 28 male rats, wistar type, ± 3 months old age and + 200 gr of each weight. Samples were divided into 4 groups of 7 rats each. Rats for control group (K) and the first treatment group (P1) will be given aquades for 14 days in a row. The second treatment group (P2) will be given watermelon juice dose I for 14 days in a row. The third treatment group (P3) will be given watermelon juice dose II for 14 days in a row. Paracetamol will be given to P1, P2, and P3, with dose 291,6 mg/200 gr weight of rats on the day 12, 13, and 14. Finally on day 15th, rats are sacrificed with neck dislocation. After that, we made preparate from the liver that painted by Hematoxillin Eosin. Preparation was observed and the score of liver damage was gained by summing up the karyopyknosis, karyorrhexis, and karyolysis cells. The data was analized by One- Way ANOVA tes (α= 0,05) and continued by Post Hoc Multiple Comparisons (LSD) test (α= 0,05). Results: Result of statistically data analysis showed that there was a significant difference of liver damage score between K-P1, K-P2, K-P3, P1-P2, P1-P3, and P2-P3. Conclusion: The feeding of watermelon juice can decrease the liver histological damage of rats induced by paracetamol and the increase of watermelon juice dose can also increase its protection effect to the liver histological damage of rats induced by paracetamol. Key words: mungbean sprout extract, paracetamol, liver histological damage.

    Item Type: Thesis (Other)
    Subjects: Q Science > Q Science (General)
    R Medicine > R Medicine (General)
    Divisions: Fakultas Kedokteran > Pendidikan Kedokteran
    Depositing User: Ayu Purnama Sari
    Date Deposited: 15 Jul 2013 21:56
    Last Modified: 15 Jul 2013 21:56
    URI: https://eprints.uns.ac.id/id/eprint/5076

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