SYNTHESIS OF CISPLATIN MODIFIED ASPIRIN AND ISONICOTINIC ACID CHLORIDE

ROSA, VENANSIA AVELIA (2019) SYNTHESIS OF CISPLATIN MODIFIED ASPIRIN AND ISONICOTINIC ACID CHLORIDE. Masters thesis, Universitas Sebelas Maret.

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    Abstract

    An aspirin ligated cisplatin derivatives, biasplatin, was prepared from acetylsalicylic anhydride and oxoplatin in DMF. Biasplatin was synthesized from oxoplatin and aspirin anhydride as starting materials by substitution reaction of hydroxo leaving groups in its axial position. The obtained biasplatin was fully characterized by FTIR, 1HNMR, 13CNMR and ESI-MS Spectroscopy. Biasplatin entrapped into MIL-101(Fe) by suspended in DMF and stirring for 72 h at ambient temperature. The slow release of biasplatin and biasplatin@MIL-101(Fe) were conducted in phosphate buffer saline solution pH 7.20 37 oC as media and measured by UV-Vis spectrophotometer. The release of biasplatin without loaded into MIL-101(Fe) is persistent for 2-3 % and biasplatin@MIL-101(Fe) is 0.05 % over 72 hours. The significant slow release of biasplatin@MIL-101(Fe) only 1 % compare to time release of biasplatin without loaded into MIL-101(Fe). Nicoplatin, cisplatin ligated isonicotinic acid, was synthesized. A substitution reaction is possibly occur on axial position of oxoplatin by isonicotinic acid ligand. The obtained compound was fully characterized with FTIR, 1HNMR, 13CNMR and ESI-MS Spectroscopy analyses. Keywords : cisplatin derivatives, biasplatin, aspirin, MIL-101(Fe), time release, nicoplatin, isonicotinic acid.

    Item Type: Thesis (Masters)
    Subjects: L Education > L Education (General)
    Divisions: Pascasarjana > Magister
    Depositing User: Mujahidah Showafah
    Date Deposited: 07 Apr 2019 03:47
    Last Modified: 07 Apr 2019 03:47
    URI: https://eprints.uns.ac.id/id/eprint/43551

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