PENGARUH PEMBERIAN QUERCETIN TERHADAP KADAR IL-8, NILAI %VEP1, DAN SKOR CAT PENDERITA PPOK STABIL

SHOLIHAH, MARATUS (2018) PENGARUH PEMBERIAN QUERCETIN TERHADAP KADAR IL-8, NILAI %VEP1, DAN SKOR CAT PENDERITA PPOK STABIL. Other thesis, Universitas Sebelas Maret.

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    Abstract

    ABSTRACT THE EFFECTS OF QUERCETIN ON IL-8 SERUM, % VEP1, AND COPD ASSESSMENT TEST SCORES IN STABLE COPD PATIENTS Maratus Sholihah, Suradi, Jatu Aphridasari, Yusup Subagio, Ana Rima Departement of Pulmonologyand Respiratory Medicine Medical Faculty of Sebelas Maret University / Dr. Moewardi General Hospital Surakarta Introduction: Chronic obstructive pulmonary disease is the leading cause of morbidity and mortality worldwide. Cigarette smoke and noxious agent result in oxidative stress and activate release of inflammatory mediators such as IL-8. Quercetin is a flavonoid compound containing anti-inflammatory effects which can be used as an adjuvant therapy in stable COPD. Objective: To analyze the effect of quercetin on serum IL-8 levels, % VEP1, and CAT score of stable COPD patients Methods: Experimental clinical trial with pretest and posttest design was performed in 30 patients with stable COPD in Dr. Moewardi Surakarta between December 2017 and january 2018. The samples taken by using purposive sampling were divided into two groups: treatment groups received standard therapy and quercetin 500mg / day for 28 days and control groups only received standard therapy. The decrease in inflammation was measured by serum IL-8 examination, improvement of obstruction measured by % VEP1, and clinical improvement measured by CAT score. Results: IL-8 serum level was significantly lower in treatment group than of in control group (p=0,001). The percentage of FEV1 was insignificant different between the two group (p=0,236). Howefer CAT score was significantly lower in treatment group compared to that of in control group (p=0,001) Conclusions: Quercetin can decrease IL-8 serum level and decrease CAT score when given in combination with standard therapy for COPD patients. Key words: stable COPD, quercetin, IL-8 serum, % FEV1, CAT score

    Item Type: Thesis (Other)
    Subjects: R Medicine > R Medicine (General)
    R Medicine > RC Internal medicine
    Divisions: Fakultas Kedokteran
    Depositing User: Rea Aisha Champa
    Date Deposited: 09 Dec 2018 20:22
    Last Modified: 09 Dec 2018 20:22
    URI: https://eprints.uns.ac.id/id/eprint/42498

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