HUBUNGAN POLIMORFISME GEN INTERLEUKIN 10 1082G/A DENGAN NEFROTOKSIK AKIBAT OBAT ANTI TUBERKULOSIS PADA PENDERITA MULTI DRUG RESISTANT TUBERCULOSIS

Umarudin , Umarudin (2018) HUBUNGAN POLIMORFISME GEN INTERLEUKIN 10 1082G/A DENGAN NEFROTOKSIK AKIBAT OBAT ANTI TUBERKULOSIS PADA PENDERITA MULTI DRUG RESISTANT TUBERCULOSIS. Masters thesis, Universitas Sebelas Maret.

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Abstract

THE CORRELATION BETWEEN INTERLEUKIN-10 1082G/A GENE POLIMORPHISM WITH NEPHROTOXICITY SECONDARY TO ANTITUBERCULOSIS TREATMENT IN MULTI DRUG RESISTANT TUBERCULOSIS PATIENTS Umarudin Introduction: T uberculosis controlling programme has become more complex with MDR-TB problem. IL-10 1082G/A gene polimorphism correlates with IL-10 secretion as anti inflammatory cytokine which plays important role in pathogenesis MDR-TB infection. The management of MDR-TB that using aminoglicoside causing nephrotoxic effect to the patients. The protective role of IL-10 from IL-10 1082 G/A genotype to nephrotoxic effect due to canamycin still becomes a prolem nowadays. Methods: This was a retrspective cohort study of MDR-TB patients who underwent treatment in Dr. Moewardi hospital IN 2011-2015. Results: There were 89 MDR-TB patients with IL-10 1082 G/A genotype polimorphism included in this study. The proportions of IL-10 1082 G/A genotype were AA genotype 13.48%, GG 4.49%, and GA 82.2%. The statistical analysis revealed that the prevalence rate differences in three groups were significant (p=0.044; p<0.05). The p value 0.044<0.05 meaning there was a significant correlation between IL-10 1082 G/A gene polimorphism with nephrotoxic onset in MDR-TB patients in Dr. Moewardi hospital. Conclusions: il-10 1082 G/A gene polimorphism had positive correlation with protection to canamycin injection nephrotoxicity in MDR-TB treatment. The onset of nephrotoxicity had positive correlation with IL-10 1082 G/A genotype polimorphism. GG genotype showed protection effect to nephrotoxicity compared to other genotypes. Key words: MDR-TB, IL-10 1082 G/A genotype polimorphism, nephrotoxicity.

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