EFEK EKSTRAK DAUN SAMBUNG NYAWA (Gynura procumbens (Lour) Merr.) TERHADAP KADAR METIL MERKURI DARAH DAN KARAKTERISTIK ERITROSIT TIKUS PUTIH (Rattus norvegicus L.) PASKA PEMAPARAN METIL MERKURI KLORIDA

Widyawati, Wiwik (2007) EFEK EKSTRAK DAUN SAMBUNG NYAWA (Gynura procumbens (Lour) Merr.) TERHADAP KADAR METIL MERKURI DARAH DAN KARAKTERISTIK ERITROSIT TIKUS PUTIH (Rattus norvegicus L.) PASKA PEMAPARAN METIL MERKURI KLORIDA. Other thesis, UNIVERSITAS SEBELAS MARET.

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    Abstract

    ABSTRACT Wiwik Widyawati. 2007. THE EFFECTS OF LEAVES SAMBUNG NYAWA (Gynura procumbens (Lour) Merr.) EXTRACT TO METHYL MERCURY CONCENTRATION IN BLOOD AND THE CHARACTERISTICS OF ERYTROCYTE AFTER EXPOSED BY METHYL MERCURY CHLORIDE OF RAT (Rattus norvegicus L.). Biologi. Faculty of Mathematics and Natural Sciences. Sebelas Maret University. Surakarta. Methyl mercury is the most toxic of the kind of mercury wich used society in various level since long ago. Naturally, methyl mercury is produced from methylation process of anorganic mercury by methanogenic bacterias on aquatic sediment. The over existency of methyl mercury in distric area will makes toxic if entry to the organism bodies. The aim of the research were to study the effects of leaves sambung nyawa (Gynura procumbens (Lour) Merr.) extract to methyl mercury concentration in blood and the characteristics of erytrocyte after exposed by methyl mercury chloride of rat (Rattus norvegicus L.) and to study the effectiveness dose of leaves sambung nyawa (Gynura procumbens (Lour) Merr.) to reduce the concentration of methyl mercury in blood and to repaire the characteristics of eritrocyte after exposed by methyl mercury chloride. The research used Completed Random Design with 6 groups, each group there were 4 repetitions. The treatments of each group were aquadest 2,5 ml (placebo), methyl mercury chloride 2.99 mg/kg BW (negative control), L-Cystein 5.4 mg/kg BW (positive control), and the extract of sambung nyawa leaves 1.945; 3.889; and 5.834 g/kg BW. The observation were included the concentration of methyl mercury in blood, hemoglobin concentration, erytrocyte number, and Packed Cell Volume (PCV), which is analyzed by Analysis of Variance (Anova) and continued with Duncan Multiple Range Test (DMRT) at significance 5 %. Morphologycal of erytrocyte observation was analyzed qualitatively. The result of the research showed that the extract of sambung nyawa leaves at dose of 1.945; 3.889; and 5.834 g/kg BW were affected to reduce the concentration of methyl mercury in blood significantly and to repaire the characteristics of erytrocyte. The extract of sambung nyawa leaves that had the highest effectiveness to reduce the methyl mercury concentration in blood and to repaire the characteristics of erytrocyte was on dose 5.834 mg/kg BW.

    Item Type: Thesis (Other)
    Subjects: Q Science > QD Chemistry
    Divisions: Fakultas Matematika dan Ilmu Pengetahuan Alam > Biologi
    Depositing User: Saputro Bagus
    Date Deposited: 15 Jul 2013 02:41
    Last Modified: 15 Jul 2013 02:41
    URI: https://eprints.uns.ac.id/id/eprint/4167

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