Perbedaan Kejadian Cognitive Impairment pada Pasien Diabetes Melitus Tipe-2 dengan Terapi Metformin dibanding Metformin dan Insulin di RSUD Dr. Moewardi

MAULIADITYA, FIRDAUS (2018) Perbedaan Kejadian Cognitive Impairment pada Pasien Diabetes Melitus Tipe-2 dengan Terapi Metformin dibanding Metformin dan Insulin di RSUD Dr. Moewardi. Other thesis, Universitas Sebelas Maret.

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    Abstract

    ABSTRACT Firdaus Mauliaditya Winda Andana, G0014102, 2018. Comparison of Cognitive Impairment Cases between Metformin and Metformin and Insulin Therapy in Type-2 Diabetes Patient in Dr. Moewardi Hospital. Essays. Faculty of Medicine, Sebelas Maret University, Surakarta. Background: Type-2 Diabetes Mellitus (DM) is a condition of metabolic disturbance due to the inability of our body to use insulin properly, causing high blood sugar levels. Type-2 DM can cause various complications, such as cognitive impairment. A lot of things can be done in order to control the blood sugar levels. One of them is the using of pharmacological therapy. Among various therapy available, the most commonly used are metformin as mono therapy and metformin and insulin as combination therapy, in which both can cause a decline in cognitive function. Metformin can cause cognitive decline by enhancing the formation of β amyloid protein which causes brain cell damage. While the uses of insulin commonly cause hypoglycemic episodes. If those episodes happen continuously in quite a long time, it can cause brain cells necrosis and eventually causing a decline in cognitive function. This study aimed to understand the difference of cognitive impairment cases in type-2 DM patients with metformin therapy compared to patient with combination of metformin and insulin therapy. Method: This study is an observational analytical with cross sectional design. The subjects were chosen using consecutive sampling. Patients’ cognitive function was measured using MMSE questionnaire. The data then analyzed using chi-square testing, the result is significant if p value < 0,05. Result: 32 patients were obtained with the number of 16 patients in each groups. In the metformin group 12 patients (37,5%) had normal cognitive function, 4 patients (12,5%) had mild cognitive impairment and 0 patients (0%) had moderate cognitive impairment. In the metformin and insulin group 10 patients (31,3%) had normal cognitive function, 5 patients (15,6%) had mild cognitive impairment and 1 patient (3,1%) had moderate cognitive impairment. The chi-square analysis with significance value α = 0,05 resulting in p value = 0.446. Conclusion: There is no significant difference of cognitive impairment cases between type-2 DM patient with metformin compared to patient with metformin and insulin therapy. Keywords: Type-2 Diabetes Mellitus, Cognitive Impairment, Metformin, Insulin, Chi-square.

    Item Type: Thesis (Other)
    Subjects: R Medicine > R Medicine (General)
    Divisions: Fakultas Kedokteran
    Fakultas Kedokteran > Pendidikan Kedokteran
    Depositing User: Fransiska Meilani f
    Date Deposited: 15 May 2018 11:44
    Last Modified: 15 May 2018 11:44
    URI: https://eprints.uns.ac.id/id/eprint/41083

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