Hubungan Faktor-faktor risiko dengan infeksi TB Laten (ITBL) pada penderita HIV

Irwandi, Delvan (2017) Hubungan Faktor-faktor risiko dengan infeksi TB Laten (ITBL) pada penderita HIV. Other thesis, Universitas Sebelas Maret.

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    Abstract

    ABSTRACT RELATION RISK FACTORS WITH LATENT TB INFECTION (LTBI) IN HIV PATIENTS Delvan Irwandi By 2014 globally 9.6 million people are infected with TB, including 1.2 million people living with HIV. HIV positive patients have a risk of TB infection or latent TB infection (ITBL) of about 5-8% per year and the risk of developing active TB 3 times higher than that of the immunocompetent individuals. The impact of HIV infection on the immune system is that CD4 + T lymphocyte cell destruction directly and indirectly leads to a quantitative decrease in CD4 + T cells. Decreased immune function in HIV infection has a direct or indirect impact on nutritional status. Nutritional status can be assessed using clinical signs, anthropometry such as BMI and biochemical indicators such as serum albumin levels. Observational epidemiological research with cross sectional design at RS Dr. Moewardi, Surakarta, Central Java, Indonesia to observe the association of risk factors with ITBL in HIV-infected patients at one period. The first step is patient and family history for recording of baseline data, past and family history, duration of antiretroviral therapy, CD4 + examination, weight and height measurements to calculate BMI / BMI, serum albumin test, immunologic examination of Tuberculin Skin Test (TST ) For dignosis ITBL. A total of 93 people meet the criteria. There was no association of age with ITBL in people with HIV (p0.501, OR 0.618, 95% CI 0.223-1.713), no association of sex with ITBL in HIV patients (p 1; OR 0,938; 95% CI 0.337-2,605) There was no correlation between the history of close contact with active tuberculosis patients with ITBL in HIV patients (p = 0.5, OR 1.268, 95% CI 1,139-1,411), no association of body mass index index with ITBL in HIV patients (p 1; OR 0.894 ; 95% CI 0.326 - 2,457), no association of serum albumin grade with ITBL in HIV patients (p 0.19; OR 1.284; 95% CI 1.147-1.436); there was a significant association of CD4 + CD4 + classification in HIV patients ( P 0.033; OR 3,560; 95% CI 1,214-10,433), there was no relationship between duration of antiretroviral therapy with ITBL in HIV patients (p 0.636; OR 0.969; 95% CI 0.244 - 3.848). HIV patients with classification advanced and severe immunosuppressive (CD4 + <350 cell/mm3) require monitoring to reduce ITBL risk. Keywords: HIV, risk of ITBL, total CD4+ <350 cell/mm3.

    Item Type: Thesis (Other)
    Subjects: R Medicine > R Medicine (General)
    Divisions: Fakultas Kedokteran > Pendidikan Kedokteran
    Depositing User: Faricha Rizqi
    Date Deposited: 25 Nov 2017 22:55
    Last Modified: 25 Nov 2017 22:55
    URI: https://eprints.uns.ac.id/id/eprint/36458

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