PENGARUH ELEKTROAKUPUNTUR PADA TITIK ZUSANLI DAN NEIGUAN TERHADAP PERBAIKAN KERUSAKAN MUKOSA ILEUM AKIBAT PEMBERIAN 5-FLUOROURASIL

PUTRI, ADHITYARI IKKE (2010) PENGARUH ELEKTROAKUPUNTUR PADA TITIK ZUSANLI DAN NEIGUAN TERHADAP PERBAIKAN KERUSAKAN MUKOSA ILEUM AKIBAT PEMBERIAN 5-FLUOROURASIL. Other thesis, Universitas Sebelas Maret.

[img] PDF - Published Version
Download (1076Kb)

    Abstract

    Background : Anticancer brings side effect in normal cells especially high proliferating cells such as gastrointestinal cells. It causes mucositis in gastrointestinal signed by decreament of villi height and crypt depth. This study intent on proofing whether electroacupuncture at Zusanli and Neiguan can accelerate mucosal recovery. Methode : 24 male Wistar rates, 3 months old, 130-200 gr, were devided into 4 groups including K, P1, P2 and P3. K was injected with 2 ml NaCl intraperitoneal on the 1 st day and sacrificed on the 7 th day. P1, P2 and P3 were injected with 150 mg/kg 5- Fluorouracyl (5-FU) intraperitoneal on the 1 st day. P1 was sacrificed on the 3 rd day and P2 on the 7 th day. P3 got EA at acupoint Zusanli and Neiguan everyday began on the 3 rd day until sacrificed on the 7 th day. EA was set on 2 Hz and 10 mA, given for 15 minutes until appear muscles contraction. Ileums were biopsied to made into histological preparation with Hematoxilin-Eosin pigmentation. Recovery of Ileum mucous was determined by summed villi hight and crypt depth (v+c) measured with micrometer under light microscope. Result: Mean of villi height for K;P1;P2;P3 are 51,56; 43,22; 54,75; 58,49 µm and mean of crypt depth are 18,5; 13,38; 17,11; 17,9 µm. Mean of (v+c) are 70,06; 56,77; 71,86; 76,43 µm. Acceleration of villi, crypt and ileum mucous recovery are significantly different between P1 and K, P2, P3. No significant different between K and P2, P3 also between P2 and P3. Conclusion: Electroacupuncture at acupoint Zusanli and Neiguan had no effect on recovery of ileum mucosal damage consequence of 5-fluorouracyl administration Keyword : Electroacupuncture, Mucositis, Ileum

    Item Type: Thesis (Other)
    Subjects: R Medicine > R Medicine (General)
    Divisions: Fakultas Kedokteran
    Fakultas Kedokteran > Pendidikan Kedokteran
    Depositing User: Andika Setiawan
    Date Deposited: 14 Jul 2013 08:01
    Last Modified: 14 Jul 2013 08:01
    URI: https://eprints.uns.ac.id/id/eprint/3591

    Actions (login required)

    View Item