Efek Hepatoprotektor Ekstrak Bunga Turi (Sesbania Grandiflora L) Terhadap Kerusakan Struktur Sel Hepar Mencit (Mus musculus) Akibat Paparan Minyak Kelapa Sawit Pemanasan Berulang

FASTIATI, RIZKA ABIDA (2017) Efek Hepatoprotektor Ekstrak Bunga Turi (Sesbania Grandiflora L) Terhadap Kerusakan Struktur Sel Hepar Mencit (Mus musculus) Akibat Paparan Minyak Kelapa Sawit Pemanasan Berulang. Other thesis, Universitas Sebelas Maret.

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    Abstract

    ABSTRACT Background: Sesbania grandiflora L flower has high antioxidant activity. This activity is caused by phytochemical ingredients of Sesbania grandiflora L flower, such as vitamin C, Flavonoids and Tannin. The aims of this research were to know the hepatoprotector effect of Sesbania grandiflora L flower’s extract to liver cell structure damage of mice caused by over reheated palm oil and to find out dose escalation of Sesbania grandiflora L flower’s extract can enhance the effect. Methods: This research was laboratory experimental research with the post-test only controlled group design. Tested animal used in this experiment were male mice Swiss webster strain.The research population were 30 male mice, that was divided into 5 groups, each group consisted of 6 mice. The negative control group (KKn) was given distilled water, the positive control group (KKp) was given over reheated palm oil. The 1st treatment group (KP1), 2nd treatment group (KP2) and 3rd treatment group (KP3) were given Over Reheated Palm Oil as much as 0.06 ml/ 20 gr BB and Sesbania grandiflora L flower’s extract with dose 7 mg/ 20 gr BB, 14 mg/ 20 gr BB and 28 mg/20 gr BB of mice. Liver histological images were assessed by the sum of the cell nucleus pyknosis, karyorrhexis, dan karyolysis. Data analyzed by using One-Way ANOVA test and Post Hoc Test LSD (α=0.05). Results: One-Way ANOVA test showed that p value is 0.000 (p < 0.05). The results of the post hoc multiple comparisons test converting the significant differences between group KKn-KKp, KKn-KP1, KKn-KP2, KKn-KP3, KKp-KP1, KKp-KP2, KKp-KP3, KP1-KP2, KP1-KP3, and KP2-KP3. Conclusions: Sesbania grandiflora L flower’s extract has a protective effect on histological structure of liver damage of mice (Mus musculus) caused by over reheated palm oil and escalated dose of Sesbania grandiflora L flower’s extract can enhance the effect. Keywords: Histological structure of liver damage, over reheated palm oil, Sesbania grandiflora L.

    Item Type: Thesis (Other)
    Subjects: R Medicine > R Medicine (General)
    Divisions: Fakultas Kedokteran
    Depositing User: Retno Andriani
    Date Deposited: 29 Aug 2017 06:11
    Last Modified: 29 Aug 2017 06:11
    URI: https://eprints.uns.ac.id/id/eprint/34249

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