THE DIFFERENCE IN SENSITIVITY AND SPECIVICITY BETWEEN NMP22 BLADDERCHECK AND URINARY CITOLOGY EXAMINATION IN PATIENTS SUSPECTED WITH BLADDER CANCER

Ahmadan, Ndaru Bintang (2017) THE DIFFERENCE IN SENSITIVITY AND SPECIVICITY BETWEEN NMP22 BLADDERCHECK AND URINARY CITOLOGY EXAMINATION IN PATIENTS SUSPECTED WITH BLADDER CANCER. Masters thesis, Universitas Sebelas Maret.

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    Abstract

    THE DIFFERENCE IN SENSITIVITY AND SPECIVICITY BETWEEN NMP22 BLADDERCHECK AND URINARY CITOLOGY EXAMINATION IN PATIENTS SUSPECTED WITH BLADDER CANCER Background : Early diagnosis in bladder cancer significantly related to patient prognosis. Gold standard examination in detecting bladder cancer is cystoscopy combined with histopathology examination. Whereas screening might be performed by urinary citology and tumor marker i.e. NMP22 Bladderchek Objective : To determine the difference in sensitivity and specivicity between NMP22 Bladderchek and urinary citology examination in patients suspected with bladder cancer Metode : This study is a diagnostic test with cross sectional approach. We are using accidental sampling, as sampling method in the present study, adjusted with restrictive criterias. Sensitivity and specivicity test was performed by using table 2x2 between NMP22 Bladderchek and urinary citology with its histopathology test result Result : Based on gender, they were 23 males (76,66%), and 7 females (23,33%). Based on age, 28 of all subjects were over 50 y.o (93,33%), while the rest 2 subjects (6,66%) were younger than 50 y.o. Of all subjects 23 (76,66%) were smokers, and others, 7 subjects (23,33%) were non smokers. Based on histopathology test results, most of all subjects with bladder cancer were transitional cell carcinoma where 1 subject belonged to grade I (3,33%), 12 subjects (40%) belonged to grade II, and 10 subjects (33,33%) belonged to grade III. Meanwhile, we found benign histopathology result in 7 subjects (23,33%). Conclusion : We found the difference in sensitivity and specivicity between NMP22 bladderchek and urinary cytology. NMP22 Bladderchek sensitivity was 91,30% (good), and specivicity 71,43% (moderate). While sensitivity of urinary cytology was 73,9% (moderate), and specivicity was 57,1% (low). NMP22 Bladderchek showed better sensitivity and specivicity compared to urinary cytology. However both examinations can not be used as replacement of histopathology as gold standart examination. Key words : Bladder cancer, urinary citology, NMP22 Bladderchek, Histopathology

    Item Type: Thesis (Masters)
    Subjects: R Medicine > R Medicine (General)
    Divisions: Pasca Sarjana > Magister > Magister Kedokteran Keluarga
    Depositing User: Gun Gun Gunawan
    Date Deposited: 25 Aug 2017 13:54
    Last Modified: 25 Aug 2017 13:54
    URI: https://eprints.uns.ac.id/id/eprint/34200

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