Hubungan asupan vitamin C dan vitamin E dalam makanan dengan kadar glutathione (GSH) pada pasien kanker payudara

ELFINA, MARISA (2017) Hubungan asupan vitamin C dan vitamin E dalam makanan dengan kadar glutathione (GSH) pada pasien kanker payudara. Masters thesis, Universitas Sebelas Maret.

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    Abstract

    MARISA ELFINA. S531408009. 2016. Hubungan Asupan Vitamin C dan Vitamin E Dalam Makanan dengan Kadar Glutathione (GSH) Pada Pasien Kanker Payudara. TESIS. Pembimbing I: Dr. dr. Sugiarto, Sp.PD, KEMD., FINASIM. Pembimbing II: Dr. Adi Magna Patriadi Nuhriawangsa, S.Pt., M.P. Program Studi Ilmu Gizi, Clinical Nutrition, Pascasarjana, Universitas Sebelas Maret. ABSTRAK Latar Belakang:Kanker merupakan salah satu penyebab kematian utama di dunia. Kanker payudara meningkatan stres oksidatif sehingga memicu kerusakan jaringan dan dapat diredam oleh senyawa yang bersifat antioksidan. GSH merupakan antioksidan endogen yang dapat apat menetralkan dan mencegah terjadinya kerusakan akibat stres oksidatif. Vitamin C dan vitamin E merupakan antioksidan eksogen yang dapat menghambat radikal bebas dan memutuskan reaksi rantai radikal. Tujuan penelitian ini menganalisis hubungan asupan vitamin C, vitamin E dengan kadar GSH pada pasien kanker payudara. Metode: Jenis penelitian adalah observasional analitik dengan desain cross sectional. Teknik sampling menggunakan konsekutif sampling. Subjek penelitian sebanyak 39 orang pasien kanker payudara rawat jalan di RSUD Dr Moewardi Surakarta yang mendapatkan kemoterapi. Penelitian dilakukan dengan teknik wawancara (food recall dan FFQ), pengukuran kadar GSH dengan ELISA kit. Analisis data menggunakan korelasi Spearman dan regresi linier ganda dengan nilai p<0,05. Hasil: Subjek penelitian memiliki rerata asupan vitamin C (86,57±45,94 mg), vitamin E (5,02±2,71 mg) dan kadar GSH (7,10±6,56 ng/ml). Hasil uji multivariat menunjukkan, pengaruh usia (B= 0,115, p=0,217), stadium (B= -1,180, p=414), kemoterapi (B= -0,399, p=0,628), asupan vitamin C (B= 0,107, p=0,001) dan vitamin E (B= 0,114, p=0,744) dengan kadar GSH. Kesimpulan: Asupan vitamin C meningkatkan kadar GSH pada pasien kanker payudara. Kata Kunci: Asupan, Vitamin C, Vitamin E, Kadar GSH, Kanker Payudara MARISA ELFINA. S531408009. 2016. Correlation Between Intake Of Vitamin C And Vitamin E With Glutathione (GSH) Levels In Breast Cancer Patients”. THESIS. Main Supervisor: Dr. dr. Sugiarto, Sp.PD, KEMD., FINASIM. Co-Supervisor: Dr. Adi Magna Patriadi Nuhriawangsa, S.Pt., M.P. Program Studi Ilmu Gizi, Clinical Nutrition, Pascasarjana, Sebelas Maret University. ABSTRACT Background: Cancer is one of the causes death in the world. Breast cancer have increased oxidative stress, triggering tissue damage and can be suppressed by antioxidants compound. GSH is an endogenous antioxidant that can be counteract oxidative stress and prevent damage due to oxidative stress. Vitamin C and vitamin E is an exogenous antioxidant that can be inhibits free radicals and decided radical chain reactions. The purpose of this study to analyze the correlation between intake of vitamin C, vitamin E with GSH levels in breast cancer patients. Methods: The study was observational analytic with cross sectional design. The sampling technique using consekutif sampling. Subject of this study was 39 breast cancer patients outpatient undergoing chemotherapy at Hospital Dr. Moewardi Surakarta.. The study was conducted by interview (food recall and FFQ), measurement of GSH levels by ELISA kit. Data analysis using spearman corelation and multiple linear regression with p<0,05. Results: Subject of this study had mean intake of vitamin C (86,57±45,94 mg), vitamin E (5,02±2,71 mg) and GSH levels (7,10±6,56 ng/ml). Results of multivariate analysis showed that the effect of age (B= 0,115, p=0,217), stage (B= -1,180, p=414), chemotherapy (B= -0,399, p=0,628), intake of vitamin C (B=0,107, p = 0.001) and vitamin E (B=0,114, p = 0.744) with GSH levels. Conclusions: Intake of vitamin C increase GSH levels in breast cancer patients. Keywords: Intake of Vitamin C, Vitamin E, GSH levels, Breast Cancer.

    Item Type: Thesis (Masters)
    Subjects: R Medicine > R Medicine (General)
    R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer)
    R Medicine > RS Pharmacy and materia medica
    Divisions: Pasca Sarjana > Magister
    Pasca Sarjana > Magister > Ilmu Gizi
    Depositing User: Tities Amrihtasari
    Date Deposited: 26 Mar 2017 17:39
    Last Modified: 26 Mar 2017 17:39
    URI: https://eprints.uns.ac.id/id/eprint/32555

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