HUBUNGAN ASUPAN EICOSAPENTAENOIC ACID DAN DOCOSAHEXAENOIC ACID DENGAN KADAR TUMOR NECROSIS FACTOR-α DAN LEAN BODY MASS PADA PASIEN KANKER PAYUDARA

PUSPARENI, LUH DESI (2017) HUBUNGAN ASUPAN EICOSAPENTAENOIC ACID DAN DOCOSAHEXAENOIC ACID DENGAN KADAR TUMOR NECROSIS FACTOR-α DAN LEAN BODY MASS PADA PASIEN KANKER PAYUDARA. Masters thesis, Universitas Sebelas Maret.

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    Abstract

    Luh Desi Puspareni, S531408030. 2016. Hubungan Asupan Eicosapentaenoic Acid Dan Docosahexaenoic Acid Dengan Kadar Tumor Necrosis Factor-α dan Lean Body Mass Pada Pasien Kanker Payudara. TESIS. Pembimbing I: Prof. Dr. Ambar Mudigdo, dr., Sp. PA(K)., Pembimbing II: Dr. Adi Magna Patriadi Nuhriawangsa, S.Pt., M.P. Program Studi Ilmu Gizi, Pascasarjana Universitas Sebelas Maret Surakarta. ABSTRAK Latar Belakang: Kanker payudara merupakan salah satu jenis kanker dengan prevalensi tertinggi di dunia termasuk Indonesia. Pada pasien kanker payudara, sitokin proinflamasi terutama tumour necrosis factor-α (TNF-α) meningkat di makrofag jaringan adiposa. Peningkatan TNF-α menyebabkan penurunan lean body mass (LBM). LBM yang rendah berhubungan dengan prognostik yang buruk, peningkatan risiko toksisitas akibat kemoterapi, serta peningkatan mortalitas pada pasien kanker. Eicosapentaenoic acid (EPA) dan docosahexaenoic acid (DHA) memiliki fungsi antiinflamasi sehingga dapat menurunkan produksi TNF-α, mencegah efek merusak dari TNF-α, dan mencegah wasting otot akibat TNF-α. Dengan demikian, penurunan LBM dapat dicegah. Tujuan penelitian ini menganalisis hubungan asupan EPA dan DHA dengan kadar TNF-α dan LBM pada pasien kanker payudara. Metode: Penelitian ini merupakan penelitian observasional dengan rancangan cross sectional pada pasien kanker payudara rawat jalan di RSUD Dr. Moewardi Surakarta. Teknik sampling yang digunakan adalah consecutive sampling dengan subjek penelitian berjumlah 34 orang. Asupan EPA dan DHA ditentukan dengan food recall 3x24 jam. Kadar TNF-α diukur dengan ELISA kit. Perhitungan LBM dilakukan dengan rumus Deurenburg. Uji statistik yang digunakan adalah regresi linier ganda. Hasil: Subjek penelitian merupakan pasien kanker stadium lanjut (III), mengalami anemia, dan 55,9% mengalami kelebihan berat badan (IMT≥25,0 kg/ m2). Rerata asupan EPA sebesar 83,31±112,88 mg/ hari dan DHA sebesar 263,19±302,82 mg/ hari. Rerata kadar TNF-α serum sebesar 33,40±5,33 pg/ml dan LBM sebesar 36,65±5,00 kg. Asupan EPA dan DHA tidak memiliki korelasi dengan kadar TNF-α dan LBM. Kesimpulan: Asupan EPA dan DHA tidak berhubungan dengan kadar TNF-α dan LBM pada pasien kanker payudara. Kata kunci: eicosapentaenoic acid, docosahexaenoic acid, tumor necrosis factor-α, lean body mass, kanker payudara Luh Desi Puspareni, S531408030. Association of Eicosapentaenoic Acid and Docosahexaenoic Acid Intake with Tumor Necrosis Factor-α and Lean Body Mass in Breast Cancer Patient. THESIS. Supervisor: Prof. Dr. Ambar Mudigdo, dr., Sp. PA(K)., co-supervisor: Dr. Adi Magna Patriadi Nuhriawangsa, S.Pt., M.P. Magister of Nutrition, Postgraduate, Sebelas Maret University, Surakarta. ABSTRACT Background: Breast cancer is one of highest prevalence cancer in the world including Indonesia. In cancer patient, proinflammatory cytokines, especially tumour necrosis factor-α (TNF-α) elevated in adipose tissue macrophages. Increased TNF-α induced lean body mass (LBM) reduction. Low lean body mass has been associated with poor prognosis, higher risk of developing treatment-related toxicity, dan increased mortality risk in cancer patient. Eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) have antiinflammatory properties to reduced production of TNF-α, prevented the damaging effect of TNF-α muscle wasting-related TNF-α. Therefore, the reduction of lean body mass can be prevented. The purpose of this study to analyze the association of EPA and DHA intake with TNF-α concentration and LBM in breast cancer patient. Method: This observational study used cross sectional design in breast cancer outpatients in Dr. Moewardi Surakarta Hospital. The sampling technique used is consecutive sampling and the number of research subject is 34 patients. EPA and DHA intake determined using 3x24 hours food recall. TNF-α concentration was measured using ELISA kit. LBM was calculated using Deurenburg equation. Results: The subject research was advanced stage cancer (stage III) patients, with anemia, and 55,9% overweight (BMI ≥25,0 kg/ m2). Average of EPA intake was 83,31±112,88 mg/ day and DHA intake was 263,19±302,82 mg/ day. Average of serum TNF-α concentration was 33,40±5,33 pg/ml and LBM was 36,65±5,00 kg. There were no correlation between EPA and DHA intake with serum TNF-α concentration (p=0,800 and 0,934). There were no correlation between EPA and DHA intake with LBM (p=0,438 and 0,175). Conclusion: EPA and DHA intake have no association with TNF-α and LBM in breast cancer patient. Keywords: eicosapentaenoic acid, docosahexaenoic acid, tumor necrosis factor-α, lean body mass, breast cancer

    Item Type: Thesis (Masters)
    Subjects: R Medicine > RA Public aspects of medicine > RA0421 Public health. Hygiene. Preventive Medicine
    Divisions: Pasca Sarjana > Magister
    Pasca Sarjana > Magister > Ilmu Gizi
    Depositing User: faizah sarah yasarah
    Date Deposited: 21 Mar 2017 12:10
    Last Modified: 21 Mar 2017 12:10
    URI: https://eprints.uns.ac.id/id/eprint/32018

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