HUBUNGAN ASUPAN ENERGI, PROTEIN, VITAMIN A, ZAT BESI, ZINC, DAN POLIMORFISME GEN INTERLEUKIN-6-174 G/C (IL-6-174 G/C) PADA PASIEN ANAK HIV

YULIANTI, ADHININGSIH (2017) HUBUNGAN ASUPAN ENERGI, PROTEIN, VITAMIN A, ZAT BESI, ZINC, DAN POLIMORFISME GEN INTERLEUKIN-6-174 G/C (IL-6-174 G/C) PADA PASIEN ANAK HIV. Masters thesis, Universitas Sebelas Maret.

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    Abstract

    Background: Human Immunodeficiency Virus infection is a global health problem including Indonesia. HIV infection in children can affect the nutritional status and immune system and can increase morbidity and mortality rate. The study aimed to analyze the relationship between intake of energy, protein, vitamin A, iron, and zinc and gene polymorphism of IL-6-174 G/C and nutritional status in HIV child patients. Methods: Observational analitics with cross sectional design was used in this study. A total of 27 pediatric HIV patients who visited Dr. Moewardi Hospital at Surakarta was selected as research subjects using a total sampling technique. Food intake was determined using 1x24-hour food recall and food frequency questionnaire. While IL-6-174 G/C gene polymorphism was analyzed using Polymerase Chain Reaction with Sequence Specific Primers (PCR-SSP). Nutritional status was assessed using body mass index for age. Data analysis used Contingency Coefficient Correlation, Spearman Correlation, and Gamma Correlation (p < 0.005) Results: HIV child patients had good food intake like energy (1914,75±611,53 kcal), protein (76,07±30,02 gr), vitamin A (601,45±220,36 mcg), Fe (12,21±4,42 mg), and Zn (8,38±3,22 mg). Energy (r = 0.015; p = 0.942) and vitamin A (r = 0.129; p = 0.521) intake was positive association with nutritional status in HIV child patients but it was not significance. Protein (r = -0.128; p = 0.524), Fe (r = -0.145; p = 0.471) and Zn intake (r = -0.041; p = 0.838) was negative association with nutritional status in HIV child patients but it was not statistically significance. GG genotype was more frequent in male than female patients, whereas CC genotype was more frequent in female than male patients with normal nutritional status. IL-6-174 G/C gene polymorphism was positive association with nutritional status in HIV child patients but did not reach significant (r = 0,220; p = 0,711). Conclusion: Some HIV child patients had IL-6-174 G/C gene polymorphism and the gene mutation was associated nutritional status. However, it was not statistically significance. Keywords: Food Intake, HIV Children, IL-6-174 G/C gene polymorphism, and nutritional status

    Item Type: Thesis (Masters)
    Subjects: R Medicine > RA Public aspects of medicine > RA0421 Public health. Hygiene. Preventive Medicine
    Divisions: Pasca Sarjana > Magister
    Pasca Sarjana > Magister > Ilmu Gizi
    Depositing User: faizah sarah yasarah
    Date Deposited: 09 Feb 2017 08:20
    Last Modified: 09 Feb 2017 08:20
    URI: https://eprints.uns.ac.id/id/eprint/31646

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