Pengaruh Kasifikasi PPOK Stabil Terhaap Hasil Uji Diffusing Capacity Of The Lung For Carbon Monoxide (DLCO) dan kadar Hemoglobin (Hb)

RIA, DINA OKFINA (2017) Pengaruh Kasifikasi PPOK Stabil Terhaap Hasil Uji Diffusing Capacity Of The Lung For Carbon Monoxide (DLCO) dan kadar Hemoglobin (Hb). Other thesis, Universitas Sebelas Maret.

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    Abstract

    Dina Okfina Ria. 2016. Pengaruh Klasifikasi PPOK Stabil terhadap Hasil Uji Diffusing Capacity of The Lung for Carbon Monoxide (DLCO) dan Kadar Hemoglobin (Hb). TESIS. Supervisor I: Prof. Dr. Suradi, dr., Sp.P(K), MARS, II, Jatu Aphridasari, dr., SpP(K). Program Studi Magister Kedokteran Keluarga Minat Utama Biomedik Program Pasca Sarjana Universitas Sebelas Maret. ABSTRAK Latar belakang: Penyakit paru obstruktif kronik (PPOK) ditandai dengan hambatan aliran udara menetap dan progresif pada jalan nafas. Penyakit ini menempati urutan pertama penyumbang angka kesakitan di seluruh dunia. DLCO digunakan untuk mengukur kecepatan tranfer gas dari alveoli ke darah kapiler dan kadar hemoglobin (Hb) merupakan salah satu faktor yang berpengaruh. Penelitian ini bertujuan untuk menilai prognosis penderita PPOK stabil melalui pemeriksaan tes fungsi paru, DLCO dan kadar Hb. Metode: Sebanyak 33 penderita PPOK stabil yang berkunjung ke Poliklinik paru RSUD Moewardi Surakarta ditetapkan sebagai responden melalui consecutive sampling. Klasifikasi PPOK menggunakan GOLD 2016. Setiap penderita diperiksa tes fungsi paru dengan spirometri, DLCO dengan single-breath dan kadar Hb dengan metode cyanmethemoglobin. Data yang diperoleh dari pemeriksaan DLCO dan kadar Hb dianalisis dengan student t test dan nilai signifikansi p < 0,05. Hasil: Rerata nilai DLCO kelompok A (100,24±31,15%) dan kelompok C (75,42±20,67%) lebih tinggi dibandingkan rerata DLCO kelompok D (46,50  17,50%). Perbedaan tersebut berbeda secara signifikan dengan p < 0,001 dan p = 0,010 secara berturut-turut. Kelompok A memiliki rerata kadar Hb tertinggi 15 ±0,72 g/dL yang diikuti kelompok D 14,23±1,50 g/dL, kelompok C 14,12±1,26 g/dL dan kelompok B 13,37±2,54 g/dL. Perbedaan kadar Hb antar kelompok tersebut tidak berbeda secara bermakna p =0,118. Simpulan: Klasifikasi penderita PPOK dengan derajat yang lebih berat memiliki nilai DLCO yang lebih rendah. Penderita PPOK stabil kelompok A mempunyai prognosis lebih baik dibandingkan kelompok B,C dan D Kata kunci: DLCO, kadar Hb, spirometri, PPOK x Dina Okfina Ria. 2016. The Effect of Stable COPD Classification on Diffusing Capacity of The lung for Carbon monoxide (DLCO) value and Hemoglobin (Hb) Level THESIS. Supervisor I: Prof. Dr. Suradi, dr., Sp.P(K), MARS, II, Jatu Aphridasari, dr., SpP(K). Master Program in Family Medicine, Post-Graduate Program, Sebelas Maret University Surakarta. ABSTRACT Background: Chronic obstructive pulmonary disease (COPD) is characterized by permanent and progressive air way obstruction. In terms of morbidity, this disease is the first highest pulmonary disease in the world. DLCO is used for measurement of gas transfer from alveoli to blood capillary and Hb level is one of the main factors affecting the gas transfer. The aim of this study was to examine prognosis of patients with stable COPD using lung function, DLCO and Hb tets. Methods: Consecutive sampling was used to recruit 33 outward patients who suffered stable COPD and visited the Lung Clinic at Public Hospital dr. Moewardi Surakarta. COPD classification was determined using GOLD 2016. Airway and lung functions were examined using spirometry and single breath DLCO. Hb level was measured using cyamethemoglobin method. All collected data were analyzed using student t test and p value was set up < 0.05. Results: DLCO value in group A and group C was 100.24±31.15% and 75.42±20.67%, higher than that of DLCO value in group D 46,50  17,50% and it reached significantly difference (p < 0,001 and p = 0,010 respectively). Higher Hb level was observed in group A (15±0.72 g/dL), followed by group D (14.23±1.50 g/dL), group C (14.12±1.26 g/dL) and group B (13.37±2.54 g/dL). However, it was not statistical difference (p =0,118). Conclusion: More severe COPD status has lower value of DLCO. Patients with stable COPD in group A have a better prognosis compared with group B, C and D. Key words: COPD, DLCO, Hb level, spirometry

    Item Type: Thesis (Other)
    Subjects: R Medicine > R Medicine (General)
    Divisions: Pasca Sarjana
    Pasca Sarjana > Magister
    Pasca Sarjana > Magister > Magister Kedokteran Keluarga
    Depositing User: Denty Marga
    Date Deposited: 09 Jan 2017 13:29
    Last Modified: 09 Jan 2017 13:29
    URI: https://eprints.uns.ac.id/id/eprint/31185

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