HUBUNGAN KADAR KORTISOL DENGAN FUNGSI KOGNITIF PADA PENGGUNA OPIOID RUMATAN METADON DI RSUD DR.MOEWARDI SURAKARTA

Prawiraningrum, Sari (2017) HUBUNGAN KADAR KORTISOL DENGAN FUNGSI KOGNITIF PADA PENGGUNA OPIOID RUMATAN METADON DI RSUD DR.MOEWARDI SURAKARTA. Masters thesis, Universitas Sebelas Maret.

[img] PDF - Published Version
Download (38Kb)

    Abstract

    Sari Prawiraningrum. S501208019. 2016. RELATIONSHIP BETWEEN CORTISOL LEVEL AND COGNITIVE FUNCTION IN METHADONE—SUBSTITUTION--OPIOID USER IN DR MOEWARDI GENERAL HOSPITAL SURAKARTA. Thesis. Supervisor I: Prof. Dr. Suroto, dr. Sp. S (K) .FAAN, II: Dr. Hari Wujoso, dr. Sp. F.MM, Master Program of Family Medicine, Main Interest on Biomedical Sciences, Sebelas Maret Surakarta University. Elevated cortisol levels in methadone substitution opioid could be a factor that affects cognitive function disorders, thus, education and appropriate treatment are necessary. This study aims to prove their relationship between cortisol levels and cognitive function in methadone substitution opioid users. The study design was a cross sectional study conducted in August-September 2016. The sampling technique was using purposive sampling, which meet the inclusion and exclusion criteria in clinic of methadone substitution of RSDM. We examined some parameters such as cortisol levels and cognitive function, and further being analyzed using bivariate regression. P value <0.05. A total of 19 subjects were included, 17 (89.5%) males and 2 (10.5%) females. 12 patients (63.2%) are joining >6 month methadone substitution and 7 patients (36.8%) join≤6 month methadone substitution group. The analysis showed that there are no significant relationship between cortisol levels and cognitive function (r = 0.44 and p >0.05). The relationship between executive, visuospatial function and cortisol levels did not show a significant association (p> 0.05). In the memory domain / delayed recall and cortisol level there are significant correlation (p <0.05). In the domain of attention and cortisol levels also shown a significant correlation (p <0.05). The correlation between duration of substitution towards cognitive function has a significant correlation (r = 0.48 and p <0.05). while the correlation between duration of substitution towards executive, visuospatial function showed no significant association (p> 0.05), on the domain of attention as erll as domain for delayed recall/memory both showed a significant association with duration of maintenance (p, 0.05). Conclusion, there is no relationship between cortisol levels and cognitive function in methadone substitution opioid users where higher cortisol level will result a poor cognitive function, but there is a relationship between cortisol levels and attention and delayed recall. Keywords:Cortisol levels, cognitive function, executive function, attention, Delayed recall

    Item Type: Thesis (Masters)
    Subjects: R Medicine > R Medicine (General)
    R Medicine > RA Public aspects of medicine
    Divisions: Pasca Sarjana
    Pasca Sarjana > Magister > Magister Kedokteran Keluarga
    Depositing User: Agista Zulfa Dini
    Date Deposited: 01 Jan 2017 19:32
    Last Modified: 01 Jan 2017 19:32
    URI: https://eprints.uns.ac.id/id/eprint/31113

    Actions (login required)

    View Item