Akurasi Uji Diagnostik Rasio Kadar Kolesterol Pleura/Serum Transudat-Eksudat dengan Kriteria Light sebagai Gold standard pada Efusi pleura

Riswandi, Aan (2016) Akurasi Uji Diagnostik Rasio Kadar Kolesterol Pleura/Serum Transudat-Eksudat dengan Kriteria Light sebagai Gold standard pada Efusi pleura. Other thesis, Universitas Sebelas Maret.

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    Abstract

    ABSTRACT DIAGNOSTICS TEST PLEURAL / SERUM CHOLESTEROL RATIO TRANSUDATE-EXUDATE BY CRITERIA LIGHT AS GOLD STANDARD IN PLEURAL EFFUSION Riswandi A1., Prof Murti B dr., MPH, Msc, PhD2, Sidharta B.R.A dr., SpPK (K)3 1. Resident, 2. Supervisor I, 3. supervisor II Master Program of Family Medicine Universitas Sebelas Maret Surakarta Background: Pleural effusion is the accumulation of excessive pleural fluid above normal volume. Examination of pleural fluid is often required by the clinician to determine transudate-exudate classification. Light’s criteria is the most common gold standard criteria for classifying transudate-exudate. Pleural fluid/serum (pf/s) cholesterol ratio is associated with inflammation that has important implications for clinical and epidemiology and relatively easy, inexpensive and can be done routinely in laboratories. Aim: To determine diagnostic test accuracy levels of pf/s cholesterol ratio transudate-exudate pleural effusion. Patients and methods: This study is a diagnostic test with cross-sectional approach, with pleural effusion patients who admitted to respirology department of RSDM Surakarta. Statistical analysis using the Shapiro Wilk ± standard deviation (± SD) for normally distributed variables and median for abnormally distributed variables. Cut-off point pf/s cholesterol ratio using ROC curve which took the most extensive AUC area. Additionally, diagnostic test are measured using 2 point 2 table and sensitivity, specificity, PPV and NPV were account. Statistical analysis was using SPSS, p <0.05. Results: Total 38 patients were included in this study. Pleural fluid/serum cholesterol ratio had median value transudate 0.09 (0.02-0.32), and median value exudative 0.53 (0.27 to 2.55), p = 0.000 (p <0.05). Based on ROC curve, AUC value was 0.993 with p = 0.000 (p <0.01). Cut-off ratio pf/s cholesterol is 0.310, with OR = 324.0, sensitivity, specificity, PPV and NPV was 94.7%. Conclusion: Diagnostic test accuracy levels pf/s cholesterol ratio with Light’s criteria as the gold standard provides excellent value in determining transudate-exudate pleural effusion. Keywords: Pleural effusion, transudate-exudate, Light’s criteria, pleural fluid/serum (pf/s) cholesterol ratio.

    Item Type: Thesis (Other)
    Subjects: R Medicine > R Medicine (General)
    Divisions: Pasca Sarjana
    Pasca Sarjana > Magister > Magister Kedokteran Keluarga
    Depositing User: Cantya Dyana Larasati
    Date Deposited: 05 Dec 2016 16:08
    Last Modified: 05 Dec 2016 16:08
    URI: https://eprints.uns.ac.id/id/eprint/30874

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