Keefektifan Pemberian Clozapin Dibandingkan Risperidon Terhadap PANSS dan Kadar Interleukin 2 Pada Pasien Skizofrenia Eksaserbasi Akut

Alit, dr, Martha Dinar (2016) Keefektifan Pemberian Clozapin Dibandingkan Risperidon Terhadap PANSS dan Kadar Interleukin 2 Pada Pasien Skizofrenia Eksaserbasi Akut. Other thesis, Universitas Sebelas Maret.

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    Abstract

    Martha Dinar Alit, S571108013. Effectiveness of the administration of clozapine compared risperidone against PANSS and the levels of IL-2 in patients with acute exacerbation of chronic schizophrenia. A Quantitative Study on RSJD dr. ARIF Zainudin Surakarta. THESIS. Supervisor I: Prof. Dr. H.Much. Syamsulhadi, dr., Sp.KJ (K) II: Prof. Dr. H.M. Fanani, dr., Sp.KJ (K) III: Adriesti Herdaetha, dr., Sp.KJ, M.H IV: Debree Septiawan, dr., SpKJ, Kes. Medical Education Program Specialist I Psychiatry Faculty of Medicine, University of Sebelas Maret / Mental Hospital of Surakarta Zainudin Arif ABSTRACT Background: Schizophrenia is a multifactorial disease, with the contribution of factors susceptible genes, epigenetic and environmental. Although the exact cause of schizophrenia is unknown, there is the possible role of the immune system in the pathogenesis of schizophrenia. Antipsychotics may have anti-inflammatory effects on the activation microglia. In study shows that nerve inflammation, immunogenetic, neurodegenerative disorders, infections, genetic DNA studies in schizophrenic patients serum concentrations of IL-2 increased. In a study by Lin et al., (2010), there is a significant decrease after therapy is given clozapine, olanzapine and risperidone Objective: To find out more on how the effectiveness of the administration of clozapine compared risperidone against PANSS and the levels of IL-2 in patients with acute exacerbation of chronic schizophrenia. Methods: The study designed Randomized Controlled Trial group, Experimental pre-post test design. Results: There was a decrease in the PANSS score clozapine and risperidone groups, but improvement PANSS score was greater in the clozapine group compared risperidone, the most prominent on the improvement of the PANSS score of negative symptoms and general psychopathology. Overall levels of IL-2 experienced a significant decline, although the results in the risperidone group is better than clozapine group. Conclusion: Clozapine has better effectiveness clinically in the treatment of patients with schizophrenia. Keywords: Interleukin-2, Schizophrenia, PANSS

    Item Type: Thesis (Other)
    Subjects: R Medicine > R Medicine (General)
    Divisions: Fakultas Kedokteran
    Depositing User: Pratama Wisnu
    Date Deposited: 03 Dec 2016 20:50
    Last Modified: 03 Dec 2016 20:50
    URI: https://eprints.uns.ac.id/id/eprint/30480

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