Pengaruh Pravastatin Terhadap Kadar IL-6 dan Lama Rawat Inap Pada Penderita Pneumonia

Yanto Lidwines Purba, Jan (2016) Pengaruh Pravastatin Terhadap Kadar IL-6 dan Lama Rawat Inap Pada Penderita Pneumonia. Masters thesis, Universitas Sebelas Maret.

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    Abstract

    Jan Yanto Lydwines Purba. S501002047. Tesis. Supervisor I: Dr. Reviono, dr., Sp.P(K), II: Prof. Dr. Suradi, dr., Sp.P(K), MARS EFFECT OF PRAVASTATIN ON LEVEL OF IL-6 AND LENGTH OF STAY IN PNEUMONIA PATIENTS. Program Study of Medicine, Post-graduate Program of Sebelas Maret University, Surakarta. ABSTRACT Background: Pneumonia is inflammation disease was caused by pathogen microbe. Inflamation reaction to eliminate pathogen microbe, but if the inflammation is too much and persistent will cause structure and function of pulmonary. The main therapy of pneumonia is antibiotic to eliminate microbe. Pravastatin has pleiotrophic effect like antiinflamation,so expecting it’s effect could diminish the inflammation and decreasing of IL-6 level and could shorten the length of stay in pneumonia patients. Method: This study is a clinical quasy experimental and was performed by using pre test and post test design. The subjects are inpatient pneumonia in Dr. Moewardi hospital in February to April 2016.Thirty subjects was taken by consecutive sampling and divided to two groups, 15 subject respectively. Result: The IL-6 level level increased from 13.31 (4.40-1025.25) (pre test) to 15.47 (1.08-854.72) (post test) in pravastatin group, and the difference was not significant statistically (p=0.776). The IL-6 level level increased from 33.31 (1.56 - 981.15) to 57.79 (8.68 - 987.82) (post test) in control group, and the difference was not significant statistically (p=0.650). There was no significant difference statistically (p=0.734) in length of stay (day) between pravastatin group 4.00 (3.00-6.00) and control group 4.00 (3.00-6.00). Conclusion: Pravastatin was decreased IL-6 level and not shortened length of stay in pneumonia patients. Keywords: pravastatin, IL-6, length of stay, pneumonia

    Item Type: Thesis (Masters)
    Subjects: R Medicine > R Medicine (General)
    Divisions: Pasca Sarjana > Magister > Magister Kedokteran Keluarga
    Depositing User: Kuni Nur Aini
    Date Deposited: 03 Nov 2016 11:57
    Last Modified: 03 Nov 2016 11:57
    URI: https://eprints.uns.ac.id/id/eprint/28219

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