Efek antipiretik ekstrak daun pare (momordica charantia l.) Pada tikus putih jantan

Ermawati, Elly Fauziah (2010) Efek antipiretik ekstrak daun pare (momordica charantia l.) Pada tikus putih jantan. Other thesis, Universitas Sebelas Maret.

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    Abstract

    Objective : The potential antipyretic effect of flavonoid in bitter melon’s leaf (Momordica charantia L.) is one of the traditional medicines that people used. This research aims to determine the antipyretic effect of the extract of bitter melon’s leaf (Momordica charantia L.) in male white mouse and determine it’s effect with paracetamol. Methods : This experimental research was arranged as a post-test only controlled group design. Thirty white mice in Wistar furrow, with 2 months of ages and 100 gram in weight were used as an animal model. Those mice were grouped equally into five, namely negative control group (2 ml water), positive control group (6,3 mg paracetamol/100 g body weight of mice/2 ml water), first dose of the extract of bitter melon’s leaf (0,756 mg/100 g body weight of mice/2ml water), second dose of the extract (1,512 mg/100 g body weight mice/2 ml water) and third dose of the extract (2,268 mg/100 g body weight mice/2 ml water). The measurement of mice temperature was conducted before and 2 hours after getting DPT vaccine, and every 30 minutes post treatment until 180 minutes. Result of this research was analyzed using anova statistical test and post hoc test. Results : The anova statistical test shows significant differences among group of variance but there is no significant differences among time of variance. Post hoc test shows significant differences beetwen negative control group, positive control group and extract of bitter melon’s leaf group. Conclusion : This research concludes that there is antipyretic effect in the extract of bitter melon’s leaf (Momordica charantia L.) in male white house but the effect is lower than paracetamol’s effect. Key Words: extract of bitter melon’s leaf, antipyretic, Momordica charantia L.

    Item Type: Thesis (Other)
    Subjects: R Medicine > R Medicine (General)
    Divisions: Fakultas Kedokteran
    Depositing User: Muhammad Yahya Kipti
    Date Deposited: 12 Jul 2013 16:26
    Last Modified: 12 Jul 2013 16:26
    URI: https://eprints.uns.ac.id/id/eprint/2546

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