PENGARUH KADAR APOLIPOPROTEIN A1 DAN DERAJAT KLINIS TERHADAP FUNGSI KOGNITIF PARKINSON

TUNJUNGSARI, RETNO (2016) PENGARUH KADAR APOLIPOPROTEIN A1 DAN DERAJAT KLINIS TERHADAP FUNGSI KOGNITIF PARKINSON. Masters thesis, Universitas Sebelas Maret.

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    Abstract

    ABSTRACT Retno Tunjungsari. S501202056. 2016. PENGARUH KADAR PLASMA APOLIPO PROTEIN A1 DAN DERAJAT KLINIS TERHADAP FUNGSI KOGNITIF PARKINSON. Thesis. Supervisor I: Dr. Diah Kurnia Mirawati, dr. Sp. S(K)., II: FX. Soetedjo, dr., Sp. S(K). Medical Family StudyProgram, Post Graduate program, Special interest Biomedical science, Universityof Sebelas Maret, Surakarta. Parkinson with severe clinical stagewill cause cognitive impairment that affect the quality of life. The role of ApolipoproteinA1 level as prognostic biomarker in cognitive impairment of Parkinson disease is extensifly less studied. Thisstudy aims to determine the relationship of plasma levels of Apolipoprotein A1 and clinical severity of Parkinson disease with cognitive impairment of Parkinson disease and thus canprovide clues for more effective therapies. The study design was a cross sectional,conducted in October- Desember 2015 with purposive sampling technique, Parkinson patient, 40-80years old, at least elementary school, outwardin RSDM. Apolipoprotein A1measurementsperformed at the laboratory of RSDM. The clinical severity of Parkinson was assessed by MOCA-ina. Variables bivariate analysis using Pearson correlation testfor numerical variables andmultivariate linear regression analysis for the value of p <0.05. Obtained 50 subjects, 62 % were male and 38% female, the mean of age 66,14± 17,71 years, the mean of Apolipoprotein A1level 106,07± 17,71 mg/dl, the mean of Parkinson’s clinical stage 2,88 ± 1,21, the mean of cognitive impairment 16,68±3,98. The results of bivariate correlation analysis showed significant association Apolipoprotein A1 levels(r = 0,754, p= 0,000), clinical stage (r = - 0,722,p = 0,000) with cognitive impairment of Parkinson disease.The results of multivariate linear regression analysis showedsignificant association Apolipoprotein A1 levels and clinical severity of Parkinson disease (p = <0.05) with cognitive impairment of Parkinson disease. Conclusion: From this study it can be concluded thatthere are significant positive correlation of Apolipoprotein A1 level, on the other hand clinical severity based on Hoen and Yahr classification also correlated with the severity of cognitive impaiment on Parkinson disease. Keywords: Apolipoprotein A1 –clinical severity of Parkinson disease- cognitive impairment of Parkinson disease

    Item Type: Thesis (Masters)
    Subjects: R Medicine > RA Public aspects of medicine
    Divisions: Pasca Sarjana
    Pasca Sarjana > Magister > Magister Kedokteran Keluarga
    Depositing User: fauzi ahmad
    Date Deposited: 19 Apr 2016 11:35
    Last Modified: 19 Apr 2016 11:35
    URI: https://eprints.uns.ac.id/id/eprint/25210

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