EFEK PEMBERIAN EKSTRAK ETHANOL PEGAGAN (Centella asiatica) TERHADAP KINERJA TIKUS (Rattus novergicus) DALAM MAZE RADIAL DELAPAN LENGAN PASCA RESTRAINT STRES

Hamidi, Baarid Luqman (2009) EFEK PEMBERIAN EKSTRAK ETHANOL PEGAGAN (Centella asiatica) TERHADAP KINERJA TIKUS (Rattus novergicus) DALAM MAZE RADIAL DELAPAN LENGAN PASCA RESTRAINT STRES. Other thesis, Universitas Sebelas Maret.

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    Abstract

    Baarid Luqman Hamidi, G0006052, 2009, THE EFFECT OF EXTRACT ETHANOL PEGAGAN (Centella asiatica) ON THE EIGHT ARM RADIAL MAZE PERFORMANCE OF RATS (Rattus Novergicus) AFTER RESTRAINT STRESS. Medical Faculty, Sebelas Maret University, Surakarta. The aim of this research was to investigate the effects of Extract Ethanol Pegagan (Centella asiatica) treatment after stressed restraint stress by measuring the eight arms radial maze performance of rats. Pre test and post test controlled group design was applied in this research. Male Wistar rats (Rattus novergicus) with the mean age of 8 weeks and the body weight of 150-200 grams which used for sample were divided randomly into 4 groups, each consists of 6 rats i.e. Control Group (without any treatment), Stress Group (was given restraint stress 2 hours/days for each rats), Pegagan Group (was given 0.3 mg/gBW/day/rat Extract Ethanol Pegagan (Centella asiatica)), Pegagan and Stress Group (was given 0.3 mg/gBW/day/rat Extract Ethanol Pegagan (Centella asiatica) and restraint stress 2 hours/days for each rats). The treatment was given for 21 days. Within 12 days for each pre and post treatment, a test on the Eight Arm Radial Maze was conucted for individual rat to observe its performance. Assesment of rats performance in the Eight Arm Radial Maze test was based error type B. Kruskall-Wallish and Mann-Whitney tests with SPSS for Windows 16 version were applied to statistically analyzed the difference between four groups. By using Kruskall-Wallish test showed that significant performance level difference between four groups of rats with p=0.001. By using Mann-Whitney test, it was found that significantly different between Stress Group and Pegagan Group (p=0.001), also Stress Group and Pegagan and Stress Group (p=0.001). There was no significant differences are showed between Control Group and Stress Group (p=0.051), Control Group and Pegagan Group (p=0.143), Control group and Pegagan and Stress Group (p=0.143) also Pegagan Group and Pegagan and Stress Group (p=0,952). It is concluded that Extract Ethanol Pegagan (Centella asiatica) improve performances of rats on the Eight Arm Radial Maze after restraint stress. Keywords: Pegagan (Centella asiatica), performance, restraint stress

    Item Type: Thesis (Other)
    Subjects: R Medicine > R Medicine (General)
    Divisions: Fakultas Kedokteran
    Depositing User: Muhammad Yahya Kipti
    Date Deposited: 12 Jul 2013 01:00
    Last Modified: 12 Jul 2013 01:00
    URI: https://eprints.uns.ac.id/id/eprint/2419

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