HUBUNGAN KADAR SERUM HS-CRP DENGAN TINGKAT KEPARAHAN STROKE ISKEMIK FASE AKUT DI RSUD Dr. MOEWARDI SURAKARTA

Kertawari B, M Iccha (2015) HUBUNGAN KADAR SERUM HS-CRP DENGAN TINGKAT KEPARAHAN STROKE ISKEMIK FASE AKUT DI RSUD Dr. MOEWARDI SURAKARTA. Masters thesis, Universitas Sebelas Maret.

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    Abstract

    M. Iccha Kertawari B. S501108052. 2015. HUBUNGAN KADAR SERUM HS-CRP DENGAN TINGKAT KEPARAHAN STROKE ISKEMIK FASE AKUT DI RSUD Dr. MOEWARDI SURAKARTA. Thesis. Supervisor I: Prof. Dr. Suroto, dr. Sp. S (K)., II: FX. Soetedjo, dr., Sp. S(K). Medical Family Study Program, Post Graduate program, Special interest Biomedical science, University of Sebelas Maret, Surakarta. Acute ischemic stroke triggers an inflammatory response causing increased levels of C-reactive protein. The role of CRP as a marker during and after an ischemic stroke is less studied extensively compared with coronary artery diseases. This study aims to determine the relationship of serum levels of high sensitivity C-reactive protein with severity of acute phase of ischemic stroke and thus can provide clues for more effective therapies. The study design was a cross sectional, conducted in April-June 2015 with purposive sampling technique, first stroke patient, the onset . 72 hours, inward in RSDM. HS-CRP measurements performed at the laboratory of RSDM. The severity of stroke was assessed by NIHSS. Variables bivariate analysis using Spearman and Pearson correlation test for numerical variables and lambda correlation test for nominal variables and multivariate linear regression analysis for the value of p <0.05. Obtained 56 subjects, 60.71% were male and 39.29% female, the mean of age 59.86 ± 1.18 years, the mean onset of hospitalized 17.21 ± 2.65 hours, the mean of taking HS-CRP from the onset 34 ± 2.62 hours and the mean of HS-CRP 1.51 ± 0.34 mg / L. The results of bivariate correlation analysis showed significant association HS-CRP levels (r = 0,300, p = 0.024) and the type of stroke based on Bamford classification (r = 0,083, p = 0.038) with the severity of the acute phase of ischemic stroke. The results of multivariate linear regression analysis showed significant association HS-CRP levels (p = <0.01) with the severity of the acute phase of ischemic stroke. Conclusion: From this study it can be concluded that there are significant positive correlation of HS-CRP level, on the other hand type of stroke based on Bamford classification also correlated with the severity of acute phase of ischemic stroke. Keywords: acute ischemic stroke - hs-CRP - severity of the stroke - NIHSS

    Item Type: Thesis (Masters)
    Subjects: R Medicine > R Medicine (General)
    Divisions: Pasca Sarjana
    Pasca Sarjana > Magister
    Pasca Sarjana > Magister > Magister Kedokteran Keluarga
    Depositing User: azaria nur fadhillah
    Date Deposited: 28 Nov 2015 21:02
    Last Modified: 28 Nov 2015 21:02
    URI: https://eprints.uns.ac.id/id/eprint/22150

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