HUBUNGAN ANTARA POLIMORFISME GEN HLA DQB1*0201 PADA KERENTANAN DAN SITOKIN IL- 10 PASIEN TB-MDR

Pakiding, Helena (2015) HUBUNGAN ANTARA POLIMORFISME GEN HLA DQB1*0201 PADA KERENTANAN DAN SITOKIN IL- 10 PASIEN TB-MDR. Masters thesis, Universitas Sebelas Maret .

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    Abstract

    Background: This study was conducted to determine association between human leukocyte antigen (HLA) DQB1* 0201 gene polymorphism and suspectibility to Multidrug resistant tuberculosis (MDR-TB) patients. Case of MDR-TB is a problem that causes morbidity and mortality. Host genetic is one of the risk factors for tuberculosis (TB) and MDR-TB influence to be susceptible or resistance to disease. Interleukin 10 is an antiinflamatory cytokine that is produced during infection. Methods: This study was a cross sectional analytic study. The subject are MDR-TB patients, Non MDR-TB patients, and healthy persons in Dr. Moewardi hospital on September-November 2014. HLA DQB1*0201 gene polymorphism analyzed with PCR in 31 MDR-TB patients, 29 non MDR-TB patients and 34 healthy persons. Level of plasma cytokine IL-10 in MDR-TB analyzed with ELISA. Results: There was no significant association between HLA DQB1*0210 gene polymorphism with MDR-TB incidence in the group of MDR and non MDR-TB (P= 0.672). There was no significant association between HLA DQB1*0201 gene polymorphism with TB incidence in the group of TB and healthy persons (P= 0.672). There were no differences in levels of plasma cytokine IL-10 between groups of MDRTB with and without HLA DQB1*0201 gene polymorphism (P = 0.193). Conclusion: HLA DQB1*0201 gene Polymorphism is not correlation with the incidence of MDR-TB and TB. No difference level of plasma cytokine IL-10 in MDRTB patients with and without HLA DQB1*0201 gene polymorphism. Key words: HLA DQB1*0201, MDR-TB, IL-10

    Item Type: Thesis (Masters)
    Subjects: R Medicine > R Medicine (General)
    Divisions: Pasca Sarjana
    Pasca Sarjana > Magister
    Pasca Sarjana > Magister > Magister Kedokteran Keluarga
    Depositing User: Afifah Nur Laili
    Date Deposited: 28 Nov 2015 10:55
    Last Modified: 28 Nov 2015 10:55
    URI: https://eprints.uns.ac.id/id/eprint/22120

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