PENGARUH MINYAK JINTAN HITAM (Nigella sativa) TERHADAP KERUSAKAN HISTOLOGIS GINJALMENCIT (Mus musculus) YANG DIINDUKSI PARASETAMOL

Shiddiqi, Toumi (2008) PENGARUH MINYAK JINTAN HITAM (Nigella sativa) TERHADAP KERUSAKAN HISTOLOGIS GINJALMENCIT (Mus musculus) YANG DIINDUKSI PARASETAMOL. Other thesis, Universitas Sebelas Maret.

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    Abstract

    Toumi Shiddiqi, G.0005196, 2008.The Influenceof Black Seed (Nigella sativa) Oil to Renal Histological Damaging of Mice (Mus musculus)that Induced by Paracetamol. Nowadays,consuming paracetamol for analgetic antipiretic is increasing. Paracetamol which used in inappropriate dose has bad effect to our body, such as nefrotoxic. Black seed (Nigella sativa) oil,which contains thymoquinone,has protection effect to renal toxicity mechanism. The aim of this research is knowing the influence of black seed (Nigella sativa)oil to renal histological damaging of mice (Mus musculus) that induced by paracetamol. This was laboratory experimental research with post test only controlledgroup design. Samples in this research were thirty male mices (Mus musculus), Swiss webster type, 6-8 weeks old age and +20 g of each weight. Samples divided into 3 groups, each group has ten mices.The control group, mices are given with aquadest twice orally perdays for a week. The first group, mices are given with paracetamol and aquadest orally perdays for 3 days. Then, the fourth until seventh day, mices are treated like the control group. The second group, mices are given with paracetamol and black seed oil orally perdays for 3 days. Then, the fourth until seventh day, mices are given with aquadest and black seed oil orally perdays. Finally in eight day, mices are sacrificed with neck dislocation. After that, we made preparate from the right and leftrenal that painted by Hematoxillin Eosin (HE). Renal histological is observed and scored base on renal histological damaging on karyopyknosis, karyorhexis, and karyolysis. Karyopyknosis is given score 1, karyorhexis is given score 2, and karyolysis is given score 3. Data are analized by One-Way ANOVA test (α = 0,05), and continued by Post Hoc Multiple Comparisons (LSD)test (α = 0,05). The result of this research showed the significant difference between control group and first group (p<0,05), control group and second group (p<0,05), first group and second group (p<0,05). According to this research, we concluded that black seed (Nigella sativa) oil was able todecrease the renal histological damaging of mice(Mus musculus) that induced by paracetamol although it could not be normal. Key words: black seed oil, paracetamol, renal histological damaging.

    Item Type: Thesis (Other)
    Subjects: R Medicine > R Medicine (General)
    Divisions: Fakultas Kedokteran
    Depositing User: Devi Nurlita Sari
    Date Deposited: 12 Jul 2013 18:42
    Last Modified: 12 Jul 2013 18:42
    URI: https://eprints.uns.ac.id/id/eprint/2107

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