PENGARUH PENJARUMAN TITIK ZUSANLI (ST36) TERHADAP PENURUNAN HITUNG LEUKOSIT PADA MENCIT (MUS MUSCULUS) MODEL SEPSIS AKIBAT PAPARAN CECAL INOKULUM

JAYANTI, ESTY (2015) PENGARUH PENJARUMAN TITIK ZUSANLI (ST36) TERHADAP PENURUNAN HITUNG LEUKOSIT PADA MENCIT (MUS MUSCULUS) MODEL SEPSIS AKIBAT PAPARAN CECAL INOKULUM. Other thesis, UNIVERSITAS SEBELAS MARET.

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    Abstract

    Background: The incidence of sepsis in the Dr. Moewardi Hospital at the end of 2007 still showed a mortality rate of 50.2 % (115 deaths from 229 patient with sepsis). Associated with sepsis treatment therapy, the use of low-dose corticosteroids in the early stages of sepsis is still debated. WHO suggests that acupuncture can stimulate corticosteroid. The aim is to know the acupuncture effect of Zusanli Point ( ST36 ) to decrease the number of leukocytes in mice (Mus musculus) model of sepsis caused by exposure to cecal inoculum. Methods: This study is an experimental laboratory with post - test only control group designs. The samples were 28 mice, divided by simple random sampling into a Control Group (KK), Sepsis Group 1 (KS1), Sepsis Group 2 (KS2), and Sepsis Group 3 (KS3). Sepsis groups were made by giving cecal inoculum exposure at a dose of 0.1 mg/mouse/day injected intraperitoneally for 7 days. During the 10 days after exposure, no treatment was given to KS1, KS2 was treated with corticosteroid therapy, and KS3 was given acupuncture therapy. The low dose corticosteroids used was Methyl prednisolone at a dose of 0.05 mg/mice that injected intraperitoneally 2 times daily. Acupuncture was given at the Zusanli point (ST36) with a duration of 15 minutes. Blood samples were taken at day 24. The leukocyte count data were analyzed with One Way ANOVA test (p < 0.05) and followed by the Bonferroni post hoc test (p > 0.005). Results: Sepsis group were successfully made by cecal inoculum exposure with significance level (p) of 0.000 (p > 0.005). Acupuncture of Zusanli Point (ST36) can reduce leucocyte count in mice (Mus musculus) model of sepsis caused by exposure to cecal inokulum as same as with corticosteroid group with significance level (p) 0.000 (p > 0.005). Conclusion: Acupuncture of Zusanli Point (ST36) can reduce leukocyte count in mice (Mus musculus) model of sepsis caused by exposure to cecal inoculum. Keywords: Acupuncture, Zusanli point (ST36), leukocyte count, Sepsis.

    Item Type: Thesis (Other)
    Subjects: R Medicine > RC Internal medicine
    Divisions: Fakultas Kedokteran
    Depositing User: Mohamad Ghulam Hirbatul Azis
    Date Deposited: 04 Sep 2015 11:56
    Last Modified: 04 Sep 2015 11:56
    URI: https://eprints.uns.ac.id/id/eprint/17807

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