PERBANDINGAN KADAR HEAT SHOCK PROTEIN 70 KETUBAN PECAH DINI DAN NORMAL PADA KEHAMILAN ATERM

Radam, Muhammad Robyanoor Ahyadi (2013) PERBANDINGAN KADAR HEAT SHOCK PROTEIN 70 KETUBAN PECAH DINI DAN NORMAL PADA KEHAMILAN ATERM. Masters thesis, Universitas Sebelas Maret.

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    Abstract

    Muhammad Robyanoor Ahyadi Radam. NIM: S500109030. 2013. Comparison Heat Shock Protein 70 Concentration Premature Rupture Of Membrane And Normal On Aterm Pregnancy. THESIS, Supervisor I: Dr. Soetrisno, dr. SpOG(K), II: Dr. Supriyadi Hari Respati, dr. SpOG. Program Study of Family Medicine Magister – Biomedic Science, Post Graduate Program, University of Sebelas Maret, Surakarta. Background: Premature rupture of membranes (PROM) an important problem in obstetric complication related to maternal stress and chorioamnitis infection, that can increase the incidence of perinatal morbidity and mortality as well as maternal. Objective: To Prove whether the levels of Heat Shock Protein 70 (Hsp70) was lower in premature rupture of membranes compared to normal pregnant women at term in order to explain occurrence of pregnancy premature rupture of membranes at term in biomolecular (Hsp70). Methods: This was an observational research and the study design was a cross- sectional study. The number of all samples was 60 women, divided into 2 groups and each group contained 30 women. Independent variable: Heat Shock Protein 70 level, Dependent variable: Premature Rupture Of Membrane. Data was analyzed by t test. Result: Based on maternal characteristic on both groups, The mean levels of Hsp70 in serum of pregnant women with PROM lower (0.36) compared to normal pregnant group (3.94) and this difference was statistically significant (p<0.001). Diagnostic value of the power levels of Hsp70 in the PROM compared with normal pregnancies analysis using Receiver Operating Characteristic curve (ROC) in SPSS 17.0 for Windows for by 0,833 or 83.3%, it can be concluded that the diagnostic value of the PROM Hsp70 levels were good (> 50%). Conclusion: The mean levels of Hsp70 in premature rupture of membranes obtained lower levels than in normal full-term pregnancy and this difference was statistically significant. Key word: Heat Shock Protein 70, PROM, Maternal Stress Muhammad Robyanoor Ahyadi Radam. NIM: S500109030. 2013. Perbandingan Kadar Heat Shock Protein 70 Ketuban Pecah Dini dan Normal pada Kehamilan Aterm. TESIS. Pembimbing I: Dr. Soetrisno, dr., SpOG(K), II: Dr. Supriyadi Hari Respati, dr., SpOG. Program Studi Magister Kedokteran Keluarga, Minat Utama Ilmu Biomedik, Universitas Sebelas Maret Surakarta. Latar Belakang: Ketuban pecah dini (KPD) merupakan masalah penting dalam obstetri berkaitan dengan stres maternal dan infeksi korioamnitis, sehingga meningkatkan morbiditas dan mortalitas perinatal maupun maternal. Tujuan penelitian: Membuktikan apakah kadar Heat Shock Protein 70 (Hsp70) lebih rendah pada ketuban pecah dini dibandingkan normal ibu hamil aterm sehingga dapat menjelaskan kejadian ketuban pecah dini kehamilan aterm secara biomolekuler (Hsp70). Metode penelitian: Penelitian observasional analitik dan desain penelitian potong lintang. Jumlah subyek penelitian adalah 60 orang, terbagi ke dalam 2 kelompok dan setiap kelompok 30 orang. Variabel independen: kadar Hsp70, Variabel dependen: KPD Hamil Aterm. Analisa statistik dengan uji t. Hasil: Berdasarkan karakteristik ibu pada kedua kelompok penelitian, Rerata kadar Hsp70 pada serum ibu hamil dengan KPD lebih rendah (0,36) dibandingkan dengan kelompok hamil normal (3,94) dan perbedaan tersebut secara statistik bermakna (p < 0,001). Nilai kekuatan diagnostik dari kadar Hsp70 pada KPD dibandingkan dengan kehamilan normal dilakukan analisa dengan menggunakan kurva Receiver Operating Characteristic (ROC) pada SPSS 17.0 for Windows sebesar sebesar 0,833 atau 83,3%, sehingga dapat disimpulkan nilai diagnostik kadar Hsp70 pada KPD adalah baik (>50%). Kesimpulan: Rerata kadar Hsp70 pada ketuban pecah dini didapatkan lebih rendah dari pada hamil aterm normal dan perbedaan ini bermakna secara statistik. Kata kunci: Heat Shock Protein 70, KPD, Stres Maternal

    Item Type: Thesis (Masters)
    Subjects: R Medicine > RG Gynecology and obstetrics
    Divisions: Pasca Sarjana > Magister > Magister Kedokteran Keluarga
    Depositing User: Nur Anisah
    Date Deposited: 03 May 2014 22:27
    Last Modified: 03 May 2014 22:27
    URI: https://eprints.uns.ac.id/id/eprint/14851

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