FORMULASI SEDIAAN EMULSI TIPE M/A MINYAK BIJI JINTEN HITAM (Nigella sativa L.) DENGAN EMULGATOR KOMBINASI SPAN 80 DAN TWEEN 80

Souvica, Royan Tia (2013) FORMULASI SEDIAAN EMULSI TIPE M/A MINYAK BIJI JINTEN HITAM (Nigella sativa L.) DENGAN EMULGATOR KOMBINASI SPAN 80 DAN TWEEN 80. Other thesis, Universitas Sebelas Maret.

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    Abstract

    ABSTRACT A study concerning the preparation of emulsion formulation of black cumin seed oil (Nigella sativa L.). Emulsion preparation is a drug dosage form which consists of two phases which consist of water and oil phases. One such phase dispersed in another phase. In this research the black cumin seed oil used, which has benefits as antiasma. In this research, the concentration of emulsifier are differences and seen its effect on the physical and chemical stability. Emulsifier used in this study was a combination of Span 80 and Tween 80 in the ratio 1:9. Variations in the concentration of emulsifier is used by 10%, 12.5% and 15%. Once the emulsion was made and then did observations of the physical stability include organoleptic, the ratio of the phase separation, viscosity, redispersibility, emulsion type, and chemical stability include pH changes for 8 weeks and test the preferences of the emulsion. Emulsion stability observations indicated the most stable was formula 3 that has the lowest ratio of phase separation and the highest viscosity. Observations indicate that the type of emulsion formula 1, 2, and 3 of type M/A and did not inversion during storage. The most difficult formula dispersed back is formula 1. The third formula showed no significant pH change and of the hedonic test is known to most preferred is formula 1. Results of statistical tests by ANOVA followed by t-LSD test showed significant differences between the three formulas include the ratio of the phase separation, viscosity and redispersibilitas, but did not show significant differences for pH changes. Keyword : Emulsion, black cumin seed oil, emulsifier, Span 80, Tween 80

    Item Type: Thesis (Other)
    Subjects: R Medicine > RS Pharmacy and materia medica
    Divisions: Lembaga Penelitian dan Pengabdian Kepada Masyarakat - LPPM
    Depositing User: Nurrahma Restia
    Date Deposited: 03 May 2014 18:36
    Last Modified: 03 May 2014 18:36
    URI: https://eprints.uns.ac.id/id/eprint/14582

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