Interleukin-4 and interferon- γ levels in Epstein-Barr virus-associated infectious mononucleosis and nasopharyngeal carcinoma

Budiani, Dyah R. and Haryana, Sofia M. and Sosroseno, Wihaskoro (2011) Interleukin-4 and interferon- γ levels in Epstein-Barr virus-associated infectious mononucleosis and nasopharyngeal carcinoma. Journal of Research in Medical Sciences, 16 (1). pp. 94-97.

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    Abstract

    Background: Cytokines have been suggested to participate in the pathogenesis of infectious mononucleosis (IM) and nasopharyngeal carcinoma (NPC). METHODS: Serum levels and gene expression of interleukin-4 (IL-4) and interferon-γ (IFN-γ) were assessed by immunologic and PCR assays, respectively in patients with Epstein-Barr virus (EBV)-associated IM and NPC and EBV nega-tive controls. RESULTS: The serum levels of IFN- γ were elevated, but those of IL-4 were decreased in IM and NPC patients as compared with those of the control group (p < 0.05). CONCLUSIONS: These results suggest that serum levels of IFN-γ may be predominant over those of IL-4 during the cours of IM and NPC.

    Item Type: Article
    Subjects: Q Science > Q Science (General)
    R Medicine > R Medicine (General)
    Divisions: Lembaga Penelitian dan Pengabdian Kepada Masyarakat - LPPM
    Depositing User: Anis Fagustina
    Date Deposited: 26 Apr 2014 17:47
    Last Modified: 26 Apr 2014 17:47
    URI: https://eprints.uns.ac.id/id/eprint/13438

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