KADAR HEAT SHOCK PROTEIN 70 PADA PERSALINAN PRETERM

Bawono, Antonius Budi Giri (2013) KADAR HEAT SHOCK PROTEIN 70 PADA PERSALINAN PRETERM. Masters thesis, Universitas Sebelas Maret.

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    Abstract

    Antonius Budi Giri Bawono, NIM S.501202010, 2013, Heat Shock Protein 70 concentration on preterm labor. THESIS, Supervisor I: Dr. Soetrisno, dr. SpOG(K), Supervisor II: Dr. Supriyadi Hari Respati, dr. SpOG. Program Study of Family Medicine Magister – Biomedic Science, Post Graduate Program, University of Sebelas Maret, Surakarta. Background: Preterm labor rate in Indonesia was 27.9%. Heat Shock Protein 70 was considered to play a role on preterm labor due to maternal distress in low social, economy and education women. Objective: Analyzing that is any difference Heat Shock Protein 70 level on preterm labor compare with normal pregnancy in Moewardi Hospital, Surakarta, Central Java. Methods: This was an observational research and the study design was a cross- sectional study. Independent variable: Heat Shock Protein 70 level, dependent variable: preterm labor. Data was analyzed by Chi square test. Result: The number of all samples was 60 women, divided into 2 groups and each group contained 30 women. Based on maternal characteristic on both groups, education and nutritional status have an effect on occurrence of preterm labor ( p = 0.008 and p = 0.002). Elementary school education women have a risk to occur preterm labor 6.6 times greater than high school education women (PR= 6.682 and p = 0.029). In other side, middle high school women have a risk to occur preterm labor 3 times greater than high school education women (PR = 3.27 and p = 0.054). Abnormal LILA have a risk to occur preterm labor 5.5 times greater than normal LILA (PR = 5.5). Women with abnormal level of HSP70 have a risk to occur preterm labor 5.2 times greater than in those with normal level (PR= 5.26 and p= 0.122). Conclusion: There was a difference on Heat Shock Protein 70 level between preterm labor and normal pregnancy, although there was no a statistic significantly. LILA and education play a significant role in preterm labor. Key word: heat shock protein 70, preterm labor, maternal distress, low social-economic-education Antonius Budi Giri Bawono, NIM S.501202010, 2013, Kadar Heat Shock Protein 70 pada persalinan preterm. TESIS, Pembimbing I: Dr. Soetrisno, dr. SpOG(K), Pembimbing II: Dr. Supriyadi Hari Respati, dr. SpOG. Program Studi Magister Kedokteran Keluarga Minat Utama Ilmu Biomedik Universitas Sebelas Maret Surakarta. Latar Belakang: Angka kejadian persalinan preterm di Indonesia sebesar 27,9%. Heat Shock Protein 70 diduga berperan dalam persalinan preterm yang disebabkan distres maternal pada ibu berstatus sosial, ekonomi dan pendidikan yang rendah. Tujuan penelitian: untuk menganalisis apakah terdapat perbedaan kadar HSP70 pada persalinan preterm dibandingkan kehamilan normal di RSUD Dr.Moewardi, Surakarta, Jawa Tengah. Metode penelitian: Penelitian observasional analitik dan desain penelitian potong lintang. Variabel independen: kadar Heat Shock Protein 70, variabel dependen: persalinan preterm. Analisa statistik dengan uji Chi kuadrat. Hasil: Jumlah subyek penelitian adalah 60 orang, terbagi ke dalam 2 kelompok dan setiap kelompok 30 orang. Berdasarkan karakteristik ibu pada kedua kelompok penelitian, pendidikan dan LILA berpengaruh terhadap kejadian persalinan preterm (p = 0,008 dan p = 0,002). Ibu berpendidikan SD mengalami persalinan preterm sebanyak 6,6 kali lebih besar (PR= 6,682 dan p = 0,029), sedangkan berpendidikan SMP berisiko mengalami persalinan preterm sebanyak 3 kali lebih besar (PR = 3,27 dan p = 0, 054) dibanding yang berpendidikan SMA. Ibu berLILA kurang memiliki risiko persalinan preterm sebanyak 5,5 kali lebih besar dibanding ibu berLILA normal (PR = 5,5). Ibu berkadar HSP70 yang tinggi (tidak normal) berisiko mengalami persalinan preterm sebanyak 5,2 kali lebih besar dibanding kehamilan normal (PR= 5,26 dan p= 0,122). Kesimpulan: ada perbedaan kadar Heat Shock Protein 70 pada ibu yang mengalami persalinan preterm dibandingkan kehamilan normal, namun didapatkan kesimpulan statistik yang tidak bermakna. LILA dan pendidikan berpengaruh bermakna terhadap kejadian persalinan preterm. Kata kunci: heat shock protein 70, persalinan preterm, distres maternal, status sosial-ekonomi-pendidikan rendah

    Item Type: Thesis (Masters)
    Subjects: R Medicine > R Medicine (General)
    Divisions: Pasca Sarjana > Magister > Magister Kedokteran Keluarga
    Depositing User: Tri Wahyu Prasetyo
    Date Deposited: 19 Apr 2014 06:56
    Last Modified: 19 Apr 2014 06:56
    URI: https://eprints.uns.ac.id/id/eprint/12210

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