Raden, Abkar (2010) PEGAGAN (Centella asiatica) EXTRACT INCREASES VAGINAL WALL THICKNESS IN MENOPAUSAL RATS. Folia Medica Indonesiana, 46 (3). pp. 222-228.

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    Painful intercourse (dyspareunia) is one of the complaints that are often found in menopausal women due to decreased kolagen.dan atrophy vaginal wall. This can lead to domestic disharmony because it can lead to divorce, affairs and domestic violence. Menopausal women growing more and more year, because of the higher life expectancy. To prevent these complaints need estrogen therapy or phytoestrogens. Centella asiatica is a phytoestrogen that can increase proliferation and collagen synthesis, is expected to occur with the administration of Centella asiatica collagen thickening and increase in vaginal wall so that the vagina becomes more elastic and repair cells that atrophy so painful intercourse can be avoided. Mechanism of thickening and increased collagen vaginal wall has not been clear. This study aims to explain the mechanism of thickening due to proliferation and maturation of epithelial and collagen synthesis increased vaginal wall Rattus norvegicus strain Wistar rats that experienced a given ovariectomy Indian pennywort extract. The research method is experimental design with posttest only control group design, by 35 female rats of Wistar strain Rattus norvegicus age of 4 months, weight 290-300 grams, conducted randomized into 4 groups, each group of seven rats. All groups performed ovariectomy. Preliminary research to determine the atrophy of the vaginal wall (on day 21). Group 1, not given the extract of Centella asiatica. Group 2, 3, 4 were given extracts of Centella asiatica on day 22 post-ovariectomy with a dose of 30mg, 60mg, 120 mg/Kbw/day for 40 days orally. Immunohistochemical examination to see the expression of estrogen receptor beta-producing cells (ER-ß) and collagenproducing cells. Histological examination to see thickening of the vaginal wall with Hematoxylin eosin staining. Results were analyzed using univariate analysis showed an increase in epithelial proliferation, maturation of the vaginal wall was significant (p <0.05), increased estrogen receptor beta and collagen was significantly (p, 0.05). Conclusion: It can be concluded that administration of Centella asiatica extract can increase epithelial proliferation of the vaginal wall through the mechanism of increased estrogen receptor beta, and collagen Keywords: Centella asiatica, vaginal epithelial proliferation, collagen synthesis, phytoestrogen

    Item Type: Article
    Subjects: R Medicine > RG Gynecology and obstetrics
    Divisions: Fakultas Kedokteran
    Depositing User: Arissa Aprilia Nurcahyani
    Date Deposited: 18 Apr 2014 22:51
    Last Modified: 18 Apr 2014 22:51

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