Efek Probiotik pada Kadar IgA Mencit Model Sepsis

Prasetyo, Diding Heri and Purwanto, Bambang (2010) Efek Probiotik pada Kadar IgA Mencit Model Sepsis. .

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    Abstract

    Probiotic is useful as immunomodulator and imunonutrition in patients with critical illness such as sepsis, but the mechanism is not entirely clear. This study was aimed to evaluate the effect of probiotic on serum IgA level in mice model of sepsis in dr. Moewardi Hospital/Faculty of Medicine, Universitas Sebelas Maret Surakarta period July 2009–2010. Eighteen males Balb/C mice were used and divided into three groups. Group I without treatment (negative control), group II which was mice model of sepsis inoculated with lipopolysaccharide (LPS)-E.coli (0.4 mg/mouse/ip), and group III was mice model of sepsis inoculated with E. coli LPS-and given probiotic. Serum IgA level was examined by ELISA. Data were analyzed statistically with one-way ANOVA. Serum IgA levels in normal mice group was 35.82±4.55 ng/mL. Exposing LPS-E. coli reduced the levels of serum IgA to 6.20±5.80 ng/mL. Administration of probiotics increased the serum IgA level to 65.07±34.97 ng/mL in mouse models of sepsis. Probiotics significantly increased serum IgA levels compared to mice model of sepsis group (65.07 ± 34.97 ng / mL vs. 6.20 ± 5.80 ng / mL, p = 0.000). In conclusion, administration of probiotics can increase the levels of serum IgA in mice model of sepsis. [MKB. 2010;42(4):175–80]. Key words: IgA , probiotic, sepsis

    Item Type: Article
    Subjects: S Agriculture > SF Animal culture
    Divisions: Fakultas Kedokteran
    Depositing User: Arissa Aprilia Nurcahyani
    Date Deposited: 18 Apr 2014 22:14
    Last Modified: 18 Apr 2014 22:14
    URI: https://eprints.uns.ac.id/id/eprint/12064

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