KADAR SOLUBLE FMS LIKE TYROSINE KINASE-1 (sFlt-1) DAN VASCULAR ENDOTHELIAL GROWTH FACTOR (VEGF) PADA USIA KEHAMILAN 8-20 MINGGU DENGAN RISIKO PREEKLAMPSIA

Wiyono, Bambang Eko (2013) KADAR SOLUBLE FMS LIKE TYROSINE KINASE-1 (sFlt-1) DAN VASCULAR ENDOTHELIAL GROWTH FACTOR (VEGF) PADA USIA KEHAMILAN 8-20 MINGGU DENGAN RISIKO PREEKLAMPSIA. Masters thesis, Universitas Sebelas Maret.

[img]
Preview
PDF - Published Version
Download (1603Kb) | Preview

    Abstract

    Bambang Eko Wiyono, NIM S.501008009. 2013. Soluble FMS-Like Tyrosine Kinase-1 (sFlt-1) and Vascular Endothelial Growth Factor (VEGF) Level in Pregnant Woman with Risk of Preeclampsia. THESSIS. Supervisor I: Dr.dr. Sri Sulistyowati, SpOG(K), II: DR.dr. Supriyadi Hari Respati, SpOG.Program Study of Family Medicine – Biomedic. Post –graduate Program of Sebelas Maret University, Surakarta Background : Preeclampsia is still a main problem for pregnant women due to its morbidity and mortality in both mother and fetus. The prevalence of preeclampsia is 3-5% among pregnant women. It’s been known that proangiogenic factor,Vascular Endothelial Growth Factor (VEGF) and anti-angionenic factor, Soluble FMS-Like Tyrosine Kinase-1 (sFlt-1) can be used for early detection in preeclampsia. Further more it can reduce morbidity and mortality Objective : To analyze Soluble FMS-Like Tyrosine Kinase-1 (sFlt-1) level and VEGF level on pregnant women with the risk of preeclampsia from 8 to 20 weeks gestational age. Material and Method : It is a quantitative observasional research with cross sectional study design. This research is obtained in Obstetrics and Gynecology Department in Moewardi Hospital, Surakarta and Prodia laboratory, Jakarta. The number of samples are 30 women, 15 pregnant women with gestasional age between 8-20 weeks and have the risk of preeclampsia, and the others in normal pregnancy. The data were measured with ELISA method for VEGF and sFlt-1 level on serum. Data were analyzed with t-test in SPSS 17.00 for windows programme. Results : sFlt-1 level in normal pregnancy was 1252,173 + 564,6461 ng/mL, and its level in those with the risk of preeclampsia was 1741,900 + 640,9700 ng/mL (p=0,023). VEGF level in normal pregnancy was 96,8800 + 144,29377 ng/mL,and its mean level in those risk of preeclampsia was 14,2400 + 8,72605 (p= 0,044). Conclusion : sFlt-1 level in the pregnancy risk of preeclampsia is higher compared with normal pregnancy and VEGF level in the pregnancy risk of preeclampsia is lower compared to normal pregnancy Keyword : Pregnancy Risk of Preeclampsia, VEGF, sFlt-1 Bambang Eko Wiyono, NIM S.501008009. 2013, Kadar Soluble FMS-Like Tyrosine Kinase-1 (sFlt-1) dan Vascular Endhothelial Growth Factor (VEGF) Pada Ibu Hamil dengan Risiko Preeklampsia. TESIS. Pembimbing I: Dr.Sri Sulistyowati,dr.SpOG(K),Pembimbing II: Dr.Supriyadi Hari Respati,dr.SpOG. Program Studi Magister Kedokteran Keluarga Minat Utama Ilmu Biomedik Universitas Sebelas Maret Surakarta. Latar Belakang : Preeklampsia saat ini masih merupakan masalah pada ibu hamil yang berhubungan dengan mortalitas dan morbiditas maternal dan neonatal. Prevalensi preeklampsia berkisar 3-5% dari kehamilan. Diketahui jika faktor proangiogenik Vascular Endhothelial Growth Factor (VEGF) dan anti-angiogenik Soluble FMS-Like Tyrosine Kinase-1 (sFLt-1) dapat digunakan sebagai deteksi dini preeklampsia, sehingga dapat digunakan sebagai upaya untuk mengurangi angka morbiditas dan mortalitas. Tujuan penelitian : Untuk analisis kadar sFlt-1 dan VEGF pada serum ibu hamil normal dan ibu hamil dengan risiko preeklampsia pada usia kehamilan 8-20 minggu. Bahan dan Cara Kerja : Kuantitatif observasional dengan metode Cross Sectional yang dilakukan di bagian Obstetri dan Ginekologi, RSUD Dr. Moewardi, Surakarta dan Laboratorium Prodia,Jakarta. Jumlah sampel yang diteliti adalah 30 sampel,terdiri dari 15 sampel hamil normal usia gestasi 8-20 mg dan 15 sampel ibu hamil dengan risiko preeklampsia. Masing – masing dianalisis kadar VEGF dan sFlt- 1 pada serumnya dengan metode ELISA dan dianalisis dengan menggunakan uji t dengan menggunakan SPSS versi 17.00 for windows. Hasil : Konsentrasi serum sFlt-1pada kehamilan normal adalah 1252,173 + 564,6461 ng/mL, pada kehamilan dengan risiko preeklampsia adalah 1741,900 + 640,9700 ng/mL(p= 0,023) , VEGF pada kehamilan normal 96,8800 + 144,29377 kelompok kehamilan normal risiko preeklampsia 14,2400 + 8,72605 (p=0,044). Kesimpulan : Kadar sFlt-1 lebih tinggi dan kadar VEGF lebih rendah pada kehamilan risiko preeklampsia dibanding kehamilan normal. Kata kunci : Kehamilan Risiko Preeklampsia, VEGF, sFlt-1.

    Item Type: Thesis (Masters)
    Subjects: R Medicine > R Medicine (General)
    R Medicine > RV Botanic, Thomsonian, and eclectic medicine
    Divisions: Pasca Sarjana > Magister > Magister Kedokteran Keluarga
    Depositing User: Tri Wahyu Prasetyo
    Date Deposited: 16 Apr 2014 22:53
    Last Modified: 16 Apr 2014 22:53
    URI: https://eprints.uns.ac.id/id/eprint/11576

    Actions (login required)

    View Item