EFEK HEPATOPROTEKTIF SEDUHAN BEKATUL BERAS HITAM (Oryza sativa L. Japonica) PADA TIKUS PUTIH YANG DIINDUKSI PARASETAMOL DOSIS TOKSIK

Burkie, Vicky Kurniawan (2011) EFEK HEPATOPROTEKTIF SEDUHAN BEKATUL BERAS HITAM (Oryza sativa L. Japonica) PADA TIKUS PUTIH YANG DIINDUKSI PARASETAMOL DOSIS TOKSIK. Other thesis, universitas sebelas maret.

[img] PDF
Download (433Kb)

    Abstract

    Objective : Black rice has long been consumed as health food because of its anthocyanin. The purpose of this study was to compare the effect of steeping black rice bran with vitamin E toward the decline of SGPT in white rats induced toxic doses of paracetamol. Method : This is a true experimental randomized control trial with posttest only group design. Thirty male white rats (Rattus norvegicus) strain Wistar 2-3 months old and weighed about 200 g were randomly divided into six treatment groups, they are: without paracetamol group (K), vitamin E + paracetamol group (P1), paracetamol only (P2), black rice bran doses 270 mg/200 g BB + paracetamol (P3), black rice bran doses 540 mg/200 g BB + paracetamol (P4) and black rice bran doses 1080 mg/200 g BB + paracetamol (P5). Each groups consist five male rats. On the 15th day, the rat’s blood were collected and tested for ALT levels. Data were analyzed by SPSS version 17.0 for Windows. Result : The data showed that average number of ALT serum group K is 24.63±6.15 IU, P1 58.80±7.09 IU, P2 176.18±118.80 IU, P3 67.93±11.85 IU, P4 56.08±7.50 IU and P5 is 99.90±42.22 IU. The results of comparative Kruskal- Wallis statistical test showed a significant difference among the six study groups p=0,03 (p <0,05). Then, The result analyzed with Mann-Whitney Test. Conclusion : The experiment shows steeping black rice bran doses 270 mg/200 g BW, 540 mg/200 g BW and 1080 mg/200 g BW have hepatoprotective effect. The mean of ALT level doses 540 mg/200 g BW is lower than vitamin E orally 100 IU/day Key words : black rice, vitamin E, paracetamol poisoning, liver damage

    Item Type: Thesis (Other)
    Subjects: R Medicine > R Medicine (General)
    Divisions: Fakultas Kedokteran > Pendidikan Kedokteran
    Depositing User: Yudha Kuntoaji
    Date Deposited: 22 Jul 2013 15:09
    Last Modified: 22 Jul 2013 15:09
    URI: http://eprints.uns.ac.id/id/eprint/8271

    Actions (login required)

    View Item